Results 21 to 30 of about 83,269 (139)

Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair [PDF]

, 2002
The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1 possesses two BRCA1 carboxyl-terminal (BRCT) protein interaction domains, denoted BRCT I and II.
Caldecott, Keith W, Taylor, Richard M, Thistlethwaite, Angela   +2 more
core   +3 more sources

The C Terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit [PDF]

, 1999
Ku is a heterodimeric protein with double-stranded DNA end-binding activity that operates in the process of nonhomologous end joining. Ku is thought to target the DNA-dependent protein kinase (DNA-PK) complex to the DNA and, when DNA bound, can interact ...
Jeggo, P A, Rottinghaus, ST, Singleton, B K, Taccioli, G E, Torres-Arzayus, M I   +4 more
core   +2 more sources

Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin[S]

Journal of Lipid Research, 2010
We examined the effect of the cellular sphingolipid level on the release of arachidonic acid (AA) and activity of cytosolic phospholipase A2α (cPLA2α) using two Chinese hamster ovary (CHO)-K1-derived mutants deficient in sphingolipid synthesis: LY-B ...
Hiroyuki Nakamura, Shigeo Wakita, Akiko Suganami, Yutaka Tamura, Kentaro Hanada, Toshihiko Murayama   +5 more
doaj   +1 more source

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

Journal of Lipid Research, 1995
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change coordinately. In an effort to identify factors mediating co-regulation, a class of suppressors of cholesterol synthesis ...
N D Ridgway
doaj   +1 more source

Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production [PDF]

, 2017
Many high-value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimise the productivity of these cultures it is important to monitor cellular metabolism, for example the utilisation
Ainsworth, C, Freemont, PS, Goers, L, Goey, CH, Kontoravdi, Polizzi, KM   +5 more
core   +1 more source

His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]

, 1988
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M., Kellerer, Albrecht M., Roos, H., Thomas, W.-H.   +3 more
core   +1 more source

Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway

Journal of Pharmacological Sciences, 2010
.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama   +7 more
doaj   +1 more source

4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture.

PLoS ONE, 2021
There is a continuous demand to improve monoclonal antibody production for medication supply and medical cost reduction. For over 20 years, recombinant Chinese hamster ovary cells have been used as a host in monoclonal antibody production due to ...
Yuichi Aki, Yuta Katsumata, Hirofumi Kakihara, Koichi Nonaka, Kenshu Fujiwara   +4 more
doaj   +1 more source

THE EFFECTS OF ELECTRICAL STIMULATION AND LASER RADIATION ON F ACTIN REORGANIZATION IN A549 AND CHO AA8 CELL LINES

International Journal of Physiotherapy, 2015
Background: The aim of this report was to determine the effects of electrical stimulation and laser radiation on non-small lung cancer (A549) and Chinese Hamster Ovary cell line (CHO AA8).
Maciej Gagat, Magdalena Izdebska, Marta Hałas-Wiśniewska, Monika Struensee, Marcin Struensee, Anna Klimaszewska-Wiśniewska, Alina Grzanka   +6 more
doaj   +1 more source

Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors

Current Therapeutic Research, 2022
: Background: The β3-adrenergic agonists vibegron and mirabegron have shown favorable safety profiles and efficacy for the treatment of overactive bladder.
Benjamin M. Brucker, MD, Jennifer King, PharmD, Paul N. Mudd, Jr, PharmD, MBA, Kimberly McHale, PhD   +3 more
doaj   +1 more source