Results 101 to 110 of about 339,190 (282)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Effects of CYP3A4 Polymorphisms on Drug Addiction Risk Among the Chinese Han Population

Frontiers in Public Health, 2019
Background:Cytochrome P450 3A4 (CYP3A4) regulates pharmacokinetic and pharmacodynamic interactions during the process of drug absorption and metabolism, suggesting CYP3A4 plays an important role in drug addiction.
Li Wang, Li Wang, Mei Bai, Mei Bai, Tianbo Jin, Tianbo Jin, Jianwen Zheng, Jianwen Zheng, Yuhe Wang, Yuhe Wang, Yongjun He, Yongjun He, Dongya Yuan, Dongya Yuan, Xue He, Xue He   +15 more
doaj   +1 more source

A Pious Couple [PDF]

, 2011
MP4 video‘A Pious Couple’ was told by Rgyal mtshan in A mdo Tibetan. Rta rgyugs, a subdivision of Rka phug Administrative Village, is a farming village located in Khams ra Town, Gcan tsa County Town, Rma lho Tibetan Autonomous Prefecture, Qinghai ...
Rdo rje don 'grub
core  

Tyrosinase gene mutations in the Chinese Han population with OCA1

Genetics Research, 2014
SummaryOculocutaneous albinism (OCA) is a heterogeneous autosomal recessive genetic disorder that affects melanin synthesis. OCA results in reduced or absent pigmentation in the hair, skin and eyes. Type 1 OCA (OCA1) is the result of tyrosinase (TYR) gene mutations and is a severe disease type.
Ning, Liu, Xiang Dong, Kong, Hui Rong, Shi, Qing Hua, Wu, Miao, Jiang   +4 more
openaire   +2 more sources

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population

Neuropsychiatric Disease and Treatment, 2020
Xiaojun Shao1 *,* Ci Yan1 *,* Dongxue Sun,1 Chunfeng Fu,1 Chunsheng Tian,1 Li Duan,1 Gang Zhu1,2 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Central Laboratory,
Shao X, Yan C, Sun D, Fu C, Tian C, Duan L, Zhu G   +6 more
doaj  

Donkey and Tiger [PDF]

, 2011
MP4 video‘Donkey and Tiger’ was told by Rgyal mtshan in A mdo Tibetan. Rta rgyugs, a subdivision of Rka phug Administrative Village, is a farming village located in Khams ra Town, Gcan tsa County Town, Rma lho Tibetan Autonomous Prefecture, Qinghai ...
Rdo rje don 'grub
core  

Genome-wide association study on serum alkaline phosphatase levels in a Chinese population [PDF]

, 2013
Background: Serum alkaline phosphatase (ALP) is a complex phenotype influenced by both genetic and environmental factors. Recent Genome-Wide Association Studies (GWAS) have identified several loci affecting ALP levels; however, such studies in Chinese ...
Dai, Xiayun, Deng, Qifei, Deng, Siyun, Guan, Lei, Gui, Lixuan, Guo, Huan, He, Meian, He, Yunfeng, Hu, Die, Hu, Frank B, Huang, Suli, Lang, Mingjian, Li, Dongfeng, Li, Jun, Lin, Dongxin, Min, Xinwen, Wang, Tian, Wu, Chen, Wu, Tangchun, Yang, Binyao, Yang, Handong, Yuan, Jing, Zhou, Li, Zhu, Jiang   +23 more
core   +2 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Analysis of MIR155HG variants and colorectal cancer susceptibility in Han Chinese population

Molecular Genetics & Genomic Medicine, 2019
Background MIR155HG plays an important role in malignant tumors, but it is rarely reported in the occurrence and development of colorectal cancer (CRC).
Huangfu Wu, Guisheng He, Hua Han, Wei Xiong, Tao Song, Huamin Chen, Xiuxiu Chen, Xiaoming Wu, Guangyue Huang, Yazhen Zhang, Chuanwei Sun, Chaoyang Zhao, Yunjing Chen   +12 more
doaj   +1 more source