Results 111 to 120 of about 459,773 (306)
Nuclear RNA sequencing of the mouse erythroid cell transcriptome
, 2012 Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Umlauf David +39 more
core +2 more sources
The ChIP-Seq tools and web server: a resource for analyzing ChIP-seq and other types of genomic data
BMC Genomics, 2016 ChIP-seq and related high-throughput chromatin profilig assays generate ever increasing volumes of highly valuable biological data. To make sense out of it, biologists need versatile, efficient and user-friendly tools for access, visualization and itegrative analysis of such data.Here we present the ChIP-Seq command line tools and web server ...
Giovanna Ambrosini +3 more
openaire +3 more sources
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
wiley +1 more source
ChIP-Seq analysis reveals direct ETS1 targets and their epigenomic features in SCC25 cells.
, 2019 (A) Heatmap of the ChIP-Seq signal at the IDR-generated consensus ETS1 binding sites across three ChIP replicates. The individual ChIP-Signal matrices were subjected to hierarchical clustering and presented as a dendrogram (B) The top de novo motif ...
Maria Tsompana (3037167) +6 more
core +1 more source
F1000Research, 2017 Motivation: The increasing availability of chromatin immunoprecipitation sequencing (ChIP-Seq) data enables us to learn more about the action of transcription factors in the regulation of gene expression.
Delasa Aghamirzaie +5 more
doaj +1 more source
Advanced Science, EarlyView.This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer +17 more
wiley +1 more source
A Clustering Approach for Motif Discovery in ChIP-Seq Dataset
Entropy, 2019 Chromatin immunoprecipitation combined with next-generation sequencing (ChIP-Seq) technology has enabled the identification of transcription factor binding sites (TFBSs) on a genome-wide scale.
Chun-xiao Sun +3 more
doaj +1 more source
Advanced Science, EarlyView.The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source