Results 61 to 70 of about 459,773 (306)
ChIP-seq analysis using PbAP2-FG2::GFP.
, 2023 (A) IGV images showing peaks identified in the ChIP-seq experiment 1 and 2 of PbAP2-FG2 on the chromosome 1. Read coverage for the ChIP data is shown. (B) IDR1D analysis between the ChIP-seq experiment 1 and 2.
Izumi Kaneko (121023) +3 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
PLoS ONE, 2011 ChIP-Seq has become the standard method for genome-wide profiling DNA association of transcription factors. To simplify analyzing and interpreting ChIP-Seq data, which typically involves using multiple applications, we describe an integrated, open source,
Eloi Mercier +5 more
doaj +1 more source
xcore: an R package for inference of gene expression regulators
BMC Bioinformatics, 2023 Background Elucidating the Transcription Factors (TFs) that drive the gene expression changes in a given experiment is a common question asked by researchers.
Maciej Migdał +7 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
MutiQC Report for Neuroblastoma Cell Line ATAC-Seq and ChIP-Seq
, 2020 MutiQC Report for Neuroblastoma Cell Line ATAC-Seq and ChIP ...
Apexa Modi (8526572) +1 more
core +1 more source
Wellington : a novel method for the accurate identification of digital genomic footprints from DNase-seq data [PDF]
, 2013 The expression of eukaryotic genes is regulated by cis-regulatory elements such as promoters and enhancers, which bind sequence-specific DNA-binding proteins.
Bonifer, Constanze +8 more
core +1 more source
ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements.
PLoS Computational Biology, 2021 Transcription factors (TFs) often function as a module including both master factors and mediators binding at cis-regulatory regions to modulate nearby gene transcription.
Xi Chen +4 more
doaj +1 more source
An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells
STAR Protocols, 2021 Summary: Integrative analysis of next-generation sequencing data can help understand disease mechanisms. Specifically, ChIP-seq can illuminate where transcription regulators bind to regulate transcription.
Lorane Texari +5 more
doaj +1 more source