Results 51 to 60 of about 3,359,139 (307)

Functional and Structural Characterization of ClC-1 and Na_v1.4 Channels Resulting from CLCN1 and SCN4A Mutations Identified Alone and Coexisting in Myotonic Patients

Cells, 2021
Non-dystrophic myotonias have been linked to loss-of-function mutations in the ClC-1 chloride channel or gain-of-function mutations in the Nav1.4 sodium channel. Here, we describe a family with members diagnosed with Thomsen’s disease. One novel mutation
Oscar Brenes, Raffaella Barbieri, Melissa Vásquez, Rebeca Vindas-Smith, Jeffrey Roig, Adarli Romero, Gerardo del Valle, Luis Bermúdez-Guzmán, Sara Bertelli, Michael Pusch, Fernando Morales   +10 more
doaj   +1 more source

Mitochondrial chloride channels – What are they for? [PDF]

FEBS Letters, 2010
This minireview focuses on observation of the properties, functional significance, and modulation of single chloride channels in the mitochondrial inner membrane using two electrophysiological methods – the patch‐clamp and bilayer lipid membrane methods. Measurements of parameters such as conductance, Cl−/K+selectivity, voltage or pH dependence as well
Tomaskova, Zuzana, Ondrias, Karol
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons

Nature Communications, 2016
Chloride regulation is important for setting GABAergic reversal potential, though tools to manipulate chloride levels are limited. Here, the authors combine Archaerhodopsin with a chloride channel opsin to generate an optogenetic chloride extrusion ...
Hannah Alfonsa, Jeremy H. Lakey, Robert N. Lightowlers, Andrew J. Trevelyan   +3 more
doaj   +1 more source

The free zinc concentration in the synaptic cleft of artificial glycinergic synapses rises to at least 1 micromolar

Frontiers in Molecular Neuroscience, 2016
Zn2+ is concentrated into presynaptic vesicles at many central synapses and is released into the synaptic cleft by nerve terminal stimulation. There is strong evidence that synaptically released Zn2+ modulates glutamatergic neurotransmission, although ...
Yan Zhang, Angelo Keramidas, Joe Lynch
doaj   +1 more source

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

The Journal of General Physiology, 2014
Calcium-mediated activation of the TMEM16A chloride channel does not depend on changes in phosphorylation status or the calcium-binding protein calmodulin.
Kuai Yu, Jinqiu Zhu, Zhiqiang Qu, Yuan-yuan Cui, C. Hartzell   +4 more
semanticscholar   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

Science, 2014
Optogenetic Insights Mapping functional neural circuits for many behaviors has been almost impossible, so Vogelstein et al. (p. 386, published online 27 March; see the Perspective by O'Leary and Marder) developed a broadly applicable optogenetic method ...
Andre Berndt, Soo Yeun Lee, C. Ramakrishnan, K. Deisseroth   +3 more
semanticscholar   +1 more source

Active Corrosion Protection of Sintered AA7075 Aluminum Alloy via Mn Powder Addition

Advanced Engineering Materials, EarlyView.
AA7075 containing Mn‐rich particles is fabricated via spark plasma sintering using AA7075 and Mn powders. Corrosion resistance is evaluated through dip‐and‐dry tests using 0.1 M NaCl (pH 6.0), and mass loss decreases with increasing Mn addition. Mn‐rich particles function as a source of Mn ions, and formation of Mn‐accumulation films on Cu‐containing ...
Ko Ebina, Masashi Nishimoto, Izumi Muto
wiley   +1 more source

Structure-Activity Relationship of Chlorotoxin-Like Peptides

Toxins, 2016
Animal venom (e.g., scorpion) is a rich source of various protein and peptide toxins with diverse physio-/pharmaco-logical activities, which generally exert their action via target-specific modulation of different ion channel functions.
Syed Abid Ali, Mehtab Alam, Atiya Abbasi, Eivind A. B. Undheim, Bryan Grieg Fry, Hubert Kalbacher, Wolfgang Voelter   +6 more
doaj   +1 more source