Results 41 to 50 of about 3,359,139 (307)
A voltage-dependent chloride channel fine-tunes photosynthesis in plants
Nature Communications, 2016 In natural habitats, plants frequently experience rapid changes in the intensity of sunlight. To cope with these changes and maximize growth, plants adjust photosynthetic light utilization in electron transport and photoprotective mechanisms.
Andrei Herdean +13 more
semanticscholar +1 more source
Chloride channels as drug targets [PDF]
Nature Reviews Drug Discovery, 2008 Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth ...
Verkman, Alan S., Galietta, Luis J. V.
openaire +3 more sources
Transient Magnetothermal Neuronal Silencing Using the Chloride Channel Anoctamin 1 (TMEM16A)
Frontiers in Neuroscience, 2018 Determining the role and necessity of specific neurons in a network calls for precisely timed, reversible removal of these neurons from the circuit via remotely triggered transient silencing.
Rahul Munshi +2 more
doaj +1 more source
Placental Chloride Channels: A Review
Placenta, 2009 The human placental syncytiotrophoblast (hSTB) is a polarized epithelial structure, that forms the main barrier to materno-fetal exchange. The chloride (Cl(-)) channels in other epithelial tissues contribute to several functions, such as maintenance of the membrane potential, volume regulation, absorption and secretion.
openaire +4 more sources
Glutamate-gated Chloride Channels [PDF]
Journal of Biological Chemistry, 2012 Glutamate-gated chloride channels (GluCls) are found only in protostome invertebrate phyla but are closely related to mammalian glycine receptors. They have a number of roles in these animals, controlling locomotion and feeding and mediating sensory inputs into behavior.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
High throughput techniques for discovering new glycine receptor modulators and their binding sites
Frontiers in Molecular Neuroscience, 2009 The inhibitory glycine receptor (GlyR) is a member of the Cys-loop receptor family that mediates inhibitory neurotransmission in the central nervous system.
Daniel F Gilbert +5 more
doaj +1 more source
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
Cell, 2008 SUMMARY Calcium-activated chloride channels (CaCCs) are major regulators of sensory transduction, epithelial secretion and smooth muscle contraction. Other crucial roles of CaCCs include action potential generation in Characean algae and prevention of ...
Björn C. Schroeder +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Frontiers in Pharmacology, 2017 Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related ...
Giulia M. Camerino +14 more
doaj +1 more source