Results 21 to 30 of about 1,671,679 (262)

Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells [PDF]

, 2009
Parasite infection can lead to alterations in the permeability of host plasma membranes. Presented here is the first demonstration that this phenomenon occurs in Plasmodium‐infected liver cells.
Staines, Henry M., Marques, Catarina A., Krishna, Sanjeev, Mota, Maria M., Derbyshire, Elvira T., Marques, CA, Prudêncio, M, Mota, MM, Staines, HM, Prudêncio, Miguel, Krishna, S, Derbyshire, ET   +11 more
core   +1 more source

Functional and Structural Characterization of ClC-1 and Na_v1.4 Channels Resulting from CLCN1 and SCN4A Mutations Identified Alone and Coexisting in Myotonic Patients

Cells, 2021
Non-dystrophic myotonias have been linked to loss-of-function mutations in the ClC-1 chloride channel or gain-of-function mutations in the Nav1.4 sodium channel. Here, we describe a family with members diagnosed with Thomsen’s disease. One novel mutation
Oscar Brenes, Raffaella Barbieri, Melissa Vásquez, Rebeca Vindas-Smith, Jeffrey Roig, Adarli Romero, Gerardo del Valle, Luis Bermúdez-Guzmán, Sara Bertelli, Michael Pusch, Fernando Morales   +10 more
doaj   +1 more source

Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance

Frontiers in Pharmacology, 2017
Chloride channels play an essential role in a variety of physiological functions and in human diseases. Historically, the field of chloride channels has long been neglected owing to the lack of powerful selective pharmacological agents that are needed to
Jonas Friard, Michel Tauc, Marc Cougnon, Vincent Compan, Christophe Duranton, Isabelle Rubera   +5 more
doaj   +1 more source

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]

, 2013
A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba, Vergani P, Töröcsik, B, Csanády, László, Csanády László, Mihályi, C, Csaba Mihályi, Paola Vergani, Vergani, Paola, Beáta Töröcsik, Szollosi, A, László Csanády, Szőllősi, András, Szöllősi András, Törőcsik, Beáta, Mihályi, Csaba, Andras Szollosi, Vergani, P, Törőcsik Beáta, Csanády, L   +19 more
core   +1 more source

Cellular role of the putative Ca2+-dependent Cl- channel bestrophin [PDF]

, 2008
Ca2+-activated Cl- channels (CaCCs) participate in a variety of important physiological processes such as transepithelial transport, olfactory and taste transduction, neuronal and cardiac excitability, fototransduction and fertility.
Barro Soria, René
core   +1 more source

Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

Mediators of Inflammation, 2015
Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction.
Monica Sala-Rabanal, Zeynep Yurtsever, Kayla N. Berry, Tom J. Brett   +3 more
doaj   +1 more source

Splicing of human chloride channel 1

Biochemistry and Biophysics Reports, 2016
Expression of chloride channel 1 (CLCN1/ClC-1) in skeletal muscle is driven by alternative splicing, a process regulated in part by RNA-binding protein families MBNL and CELF.
Takumi Nakamura, Natsumi Ohsawa-Yoshida, Yimeng Zhao, Michinori Koebis, Kosuke Oana, Hiroaki Mitsuhashi, Shoichi Ishiura   +6 more
doaj   +1 more source

Chloride diffusion coeficient determination for specifications [PDF]

, 2005
Presented at the 6th International Congress on Global Construction, Dundee, ScotlandThe chloride diffusion resistance of reinforced concrete can have a major influence on durability.
Richardson, Mark G., Callanan, Thomas, McNally, Ciaran, Evans, Conor   +3 more
core   +1 more source

Chloride channels and the reactions of cells to topography [PDF]

European Cells & Materials, 2001
The reactions of rat epitenon cells to substratum topography on the micrometric and nanometric scale such as groove-ridge structures include cell extension, elongation and orientation reactions.
G Tobasnick, ASG Curtis
doaj   +1 more source

Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

eLife, 2018
Light-gated chloride channels are emerging as promising optogenetic tools for inhibition of neural activity. However, their effects depend on the transmembrane chloride electrochemical gradient and may be complex due to the heterogeneity of this gradient
Jessica E Messier, Hongmei Chen, Zhao-Lin Cai, Mingshan Xue   +3 more
doaj   +1 more source