Results 21 to 30 of about 3,359,139 (307)
Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
Nature Communications, 2019 The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability, smooth muscle contraction, fluid secretion and gut motility.
S. Le +3 more
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Structure and function of the cystic fibrosis transmembrane conductance regulator
Brazilian Journal of Medical and Biological Research, 1999 Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR). Mutations in the CFTR gene may result in a defective processing of its protein and alter the function and ...
M.M. Morales, M.A.M. Capella, A.G. Lopes
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Chloride channels and the reactions of cells to topography [PDF]
European Cells & Materials, 2001 The reactions of rat epitenon cells to substratum topography on the micrometric and nanometric scale such as groove-ridge structures include cell extension, elongation and orientation reactions.
G Tobasnick, ASG Curtis
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Experimental and Molecular Medicine, 2019 Cancer: chloride transport protein protects tumors A chloride channel, a membrane protein involved in chloride transport, indirectly regulates calcium signaling to protect cancer cells from free radicals and DNA damage.
Jae-Rin Lee +5 more
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PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Science, 2019 A new protein channel family Exposure of cells to acidic conditions outside the cell activates chloride-conducting channels that influence physiological and pathological processes. Yang et al.
Junhua Yang +7 more
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CLCN2 Chloride Channel Mutations in Familial Hyperaldosteronism Type II
Nature Genetics, 2018 Primary aldosteronism, a common cause of severe hypertension1, features constitutive production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial hyperaldosteronism type II (FH-II)2 and 80 additional probands with unsolved ...
U. Scholl +28 more
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Structure of the human ClC-1 chloride channel
PLoS Biology, 2019 ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation.
Kaituo Wang +17 more
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Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
eLife, 2017 The calcium-activated chloride channel TMEM16A is a member of a conserved protein family that comprises ion channels and lipid scramblases. Although the structure of the scramblase nhTMEM16 has defined the architecture of the family, it was unknown how a
C. Paulino +6 more
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Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
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Cryo-EM structures of the TMEM16A calcium-activated chloride channel
Nature, 2017 Calcium-activated chloride channels (CaCCs) encoded by TMEM16A control neuronal signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic movements of the gastrointestinal system. To understand how CaCCs mediate and control
S. Dang +15 more
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