Results 31 to 40 of about 3,359,139 (307)
Mediators of Inflammation, 2015 Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction.
Monica Sala-Rabanal +3 more
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A Cell-Based Double Reporter Gene Splicing Assay for Therapeutic Screening in Myotonic Dystrophy
The EuroBiotech Journal, 2023 The study has developed a model splicing construct assay system based on splicing misregulation, one of the major molecular features associated with myotonic dystrophy.
Udosen Inyang U. +2 more
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Frontiers in Genetics, 2023 Myotonia congenita (MC) is a rare neuromuscular disease caused by mutations within the CLCN1 gene encoding skeletal muscle chloride channels. MC is characterized by delayed muscle relaxation during contraction, resulting in muscle stiffness.
Nurul Huda Musa +16 more
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Pathomechanisms of a CLCN1 Mutation Found in a Russian Family Suffering From Becker's Myotonia
Frontiers in Neurology, 2020 Objective: Myotonia congenita (MC) is a rare muscle disease characterized by sarcolemma over-excitability inducing skeletal muscle stiffness. It can be inherited either as an autosomal dominant (Thomsen's disease) or an autosomal recessive (Becker's ...
Concetta Altamura +10 more
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Splicing of human chloride channel 1
Biochemistry and Biophysics Reports, 2016 Expression of chloride channel 1 (CLCN1/ClC-1) in skeletal muscle is driven by alternative splicing, a process regulated in part by RNA-binding protein families MBNL and CELF.
Takumi Nakamura +6 more
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The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.
Journal of the American Society of Nephrology, 2017 Chloride transport by the renal tubule is critical for blood pressure (BP), acid-base, and potassium homeostasis. Chloride uptake from the urinary fluid is mediated by various apical transporters, whereas basolateral chloride exit is thought to be ...
J. Hennings +17 more
semanticscholar +1 more source
Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans
eLife, 2021 The ability of animals to process dynamic sensory information facilitates foraging in an ever-changing environment. However, molecular and neural mechanisms underlying such ability remain elusive.
Chanhyun Park +5 more
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Development of chloride channel modulators
Kidney International, 1995 Chloride channels are ubiquitously distributed, biophysically varied and functionally diverse. Despite the known contribution of chloride channels to the physiology of various cell types and the pathology of several diseases, high affinity ligands are not available to study these channels.
Singh, Ashvani K. +2 more
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eLife, 2018 Light-gated chloride channels are emerging as promising optogenetic tools for inhibition of neural activity. However, their effects depend on the transmembrane chloride electrochemical gradient and may be complex due to the heterogeneity of this gradient
Jessica E Messier +3 more
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Chloride channels in the eel intestine [PDF]
Journal of Experimental Biology, 1999 ABSTRACT Patches of freshly isolated epithelial cells from eel Anguilla anguilla intestine bathed by the same solution on both sides in the cell-attached configuration had conductances of 57.0±1.8 pS (for positive voltages) and 13.3±0.7 pS (for negative voltages) (means ± S.E.M., N=25).
, Bicho, , Ferreira, , Ferreira
openaire +2 more sources