Results 1 to 10 of about 3,359,139 (307)
CFTR Protein: Not Just a Chloride Channel? [PDF]
Cells, 2021 Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein called Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Laurence Hanssens, Jean Duchateau
exaly +3 more sources
Inhibition of the proton-activated chloride channel PAC by PIP2 [PDF]
eLife, 2023 Proton-activated chloride (PAC) channel is a ubiquitously expressed pH-sensing ion channel, encoded by PACC1 (TMEM206). PAC regulates endosomal acidification and macropinosome shrinkage by releasing chloride from the organelle lumens. It is also found at
Ljubica Mihaljević +4 more
doaj +2 more sources
Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance
Frontiers in Pharmacology, 2017 Chloride channels play an essential role in a variety of physiological functions and in human diseases. Historically, the field of chloride channels has long been neglected owing to the lack of powerful selective pharmacological agents that are needed to
Jonas Friard +5 more
doaj +2 more sources
ClC-1 Chloride Channel: Inputs on the Structure–Function Relationship of Myotonia Congenita-Causing Mutations [PDF]
Biomedicines, 2023 Myotonia congenita is a hereditary muscle disease mainly characterized by muscle hyperexcitability, which leads to a sustained burst of discharges that correlates with the magnitude and duration of involuntary aftercontractions, muscle stiffness, and ...
Oscar Brenes +2 more
doaj +2 more sources
Structure of the CLC-1 chloride channel from Homo sapiens
eLife, 2018 CLC channels mediate passive Cl− conduction, while CLC transporters mediate active Cl− transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence.
Eunyong Park, Roderick MacKinnon
doaj +2 more sources
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC [PDF]
eLife, 2022 Desensitization is a common property of membrane receptors, including ion channels. The newly identified proton-activated chloride (PAC) channel plays an important role in regulating the pH and size of organelles in the endocytic pathway, and is also ...
James Osei-Owusu +6 more
doaj +2 more sources
Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
Nature, 2017 Cristina Paulino +2 more
exaly +2 more sources
TMC4 is a novel chloride channel involved in high-concentration salt taste sensation
Journal of Physiological Sciences, 2021 “Salty taste” sensation is evoked when sodium and chloride ions are present together in the oral cavity. The presence of an epithelial cation channel that receives Na+ has previously been reported. However, no molecular entity involving Cl− receptors has
Y. Kasahara +13 more
semanticscholar +1 more source
CLN7 is an organellar chloride channel regulating lysosomal function
Science Advances, 2021 The disease-associated protein CLN7 forms an organellar chloride channel and regulates lysosomal calcium signaling and function.
Y. Wang +12 more
semanticscholar +1 more source
Frontiers in Plant Science, 2022 Nitrate accumulation in tobacco (Nicotiana tabacum L.) leaf, particularly in the burley (BU) type, is a reservoir for the generation of nitrosating agents responsible for the formation of tobacco-specific nitrosamines (TSNAs).
Lucien Bovet +11 more
doaj +1 more source