On the deprotonation of chlorothiazide. [PDF]
Acta Crystallogr C Struct ChemThe structures of the Na and K salt forms of chlorothiazide have been re‐investigated and are found to have different hydration states and deprotonation sites from those described previously. The structure of the Cs salt form is found to contain the same anion as in the new models for the Na and K salt forms.Three alkali metal salt forms of the ...
Brydson RKH +5 more
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Clinical Evaluation of Chlorothiazide [PDF]
Circulation, 1959 In the 2 years chlorothiazide has been available, it has been demonstrated to have many of the characteristics of the ideal diuretic agent. It has become an important drug in the treatment of patients with edema and hypertension. Experience has indicated that the side effects and toxic reactions are not severe nor do they prohibit long-term use of the ...
Walter M. Kirkendall
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AQbD TLC-densitometric method approach along with green fingerprint and whiteness assessment for quantifying two combined antihypertensive agents and their impurities [PDF]
BMC ChemistryPreserving the environment, reducing the amount of waste resulting from chemical trials, and reducing the amount of energy consumed have currently become a pivotal global trend.
Hend M. Nagieb +4 more
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The Renal Action of Chlorothiazide [PDF]
Proceedings of the Royal Society of Medicine, 1960 A G Spencer
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A monoclinic polymorph of chlorothiazide
Acta Crystallographica Section E: Crystallographic CommunicationsA new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than ...
Rowan K. H. Brydson, Alan R. Kennedy
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Combination diuretic therapies in heart failure: Insights from GUIDE-IT [PDF]
American Heart Journal PlusIntroduction: Diuretics are the mainstay of maintaining and restoring euvolemia in the management of heart failure. Loop diuretics are often preferred, however, combination diuretic therapy (CDT) with a thiazide diuretic is often used to overcome ...
Jeffery Budweg +8 more
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Chlorothiazide and Hydrochlorothiazide in Management of Hypertension [PDF]
BMJ, 1960 H. Smirk, E. G. McQueen, R. Morrison
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Actions of Chlorothiazide in Hypertension [PDF]
Proceedings of the Royal Society of Medicine, 1960 C. T. Dollery +2 more
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Diuretic Resistance Treated with Low-Dose Hydralazine: A Case Report and Review of the Literature
Case Reports in Nephrology and Dialysis, 2021 We present a case of severe diuretic resistance and edema from acute cardiorenal syndrome complicating heart failure with preserved ejection fraction (HFpEF) and mild alcoholic liver disease.
Mohammed Alshehri, Christopher Wilcox
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Decongestive diuresis using combination intravenous loop diuretics plus chlorothiazide in type 1 acute cardiorenal syndrome and worsening acute kidney injury; a neglected paradigm in resource-poor settings [PDF]
Journal of Nephropharmacology, 2020 Over the last decade or more, there has grown a body of evidence demonstrating that renal dysfunction in heart failure is a combination of forward failure from reduced cardiac output and therefore reduced glomerular filtration rate, as well as ...
Macaulay Amechi Chukwukadibia Onuigbo
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