Results 11 to 20 of about 5,666 (226)
Transdifferentiation of Integrin Beta 1 High+ Skin Progenitor Cells Into Functional Hepatocytes. [PDF]
Stem Cells IntA highly reproducible and functional liver model that closely resembles the human liver plays a crucial role in drug development, disease research, personalized medicine, and regenerative medicine. This study aimed to establish an in vitro liver model using skin epidermal progenitor cells (EPCs), which are easily accessible and exhibit a high ...
Lim JH, Kim DH, Lee J, Jung CR, Kang HM.
europepmc +2 more sources
Diazoxide-responsive hyperinsulinaemic hypoglycaemia in tyrosinaemia type 1
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Tyrosinaemia type 1 (TT1) is a rare inherited disorder of amino acid metabolism typically presenting with liver failure and renal tubular dysfunction. We describe three individuals with TT1 and transient hyperinsulinaemic hypoglycaemia (HH). Two siblings
Ellada Sotiridou +8 more
doaj +1 more source
Efficacy of pharmacologic therapies in patients with acute heart failure: A network meta-analysis
Frontiers in Pharmacology, 2022 Background: A network meta-analysis (NMA) of the current recommended drugs for the treatment of acute heart failure (AHF), was performed to compare the relative efficacy.Methods: We used PubMed, EMBASE, Cochrane Clinical Trials Register, and Web of ...
Hengheng Dai +7 more
doaj +1 more source
Pharmaceutics, 2021 The mechanochemical synthesis of drug–drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported.
Guadalupe Coyote-Dotor +9 more
doaj +1 more source
Structure of benzothiadiazine at zwitterionic phospholipid cell membranes [PDF]
, 2021 The use of drugs derived from benzothiadiazine, which is a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension (treated with diuretics such as bendroflumethiazide or chlorothiazide), low blood sugar (treated with non-diuretic diazoxide) or the human immunodeficiency virus, among others.
arxiv +1 more source
Clinical Case Reports, Volume 11, Issue 11, November 2023., 2023 Key Clinical Messages Diagnosis of rare even can be missed due to less familiarity with the disorder. In patients with muscle weakness, infectious causes are prioritized. Electrolyte profile not only identifies the problem, but also prevents unnecessary workup.
Sahar Noor +8 more
wiley +1 more source
ESC Heart Failure, Volume 10, Issue 5, Page 2837-2842, October 2023., 2023 Abstract Aims Heart failure (HF) is usually associated with complications of other organs. Renal impairment is seen in a significant proportion of HF patients and is characterized by worsening renal function (WRF). WRF can be used for predicting symptom exacerbation in systolic HF.
Amirhosein Ghafouri Asbagh +3 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 63, Issue 9, Page 975-992, September 2023., 2023 Abstract Nonsteroidal anti‐inflammatory drugs (NSAIDs) are commonly used for the management of fever, pain, and inflammation. However, they have always been considered to have a double‐faced role, according to their capacity to manage inflammation but also their possible reduction of immune system response and diagnosis delay.
Gianmarco Marcianò +3 more
wiley +1 more source
Fracture risk and opioid use in patients aged 17–64 years: An analysis of administrative claims data
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 9, Page 913-921, September 2023., 2023 Abstract Study Objective The objective of this work is to describe the risk of fracture in adults aged 17 to 64 years across categories of daily opioid dose. Design A retrospective analysis of insurance claims data. Data source Information from a private health insurance provider for the years 2003–2014 for enrolled individuals living in Iowa ...
Jonathan Davis +3 more
wiley +1 more source