Results 11 to 20 of about 663,360 (333)
Comparison of Human Factor IX Abundance and mRNA Expression Levels In Stable Insect and Mammalian Cells [PDF]
Journal of Cell and Molecular Research, 2017 In the production of recombinant proteins, the selection of an expression system is very important. Although CHO cells are used as mammalian expression system, the ability of insect Schneider line 2 (S2) cells as a new expression system for the high ...
Jafar Vatandoost, Shadi Tirdad
doaj +1 more source
CHO Cells Can Make More Protein [PDF]
Cell Systems, 2016 A new comprehensive genome-scale metabolic model of Chinese hamster ovary cells identifies pathways for improving biopharmaceutical protein production.
Sarah W, Harcum, Kelvin H, Lee
openaire +2 more sources
Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability
Biological Research, 2020 Background Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the productivity of CHO cells. Executive
Fatemeh Safari +5 more
doaj +1 more source
Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for immunohistochemical analysis
Biochemistry and Biophysics Reports, 2021 TROP2 is a type I transmembrane glycoprotein originally identified in human trophoblast cells that is overexpressed in several types of cancer. To better understand the role of TROP2 in cancer, we herein aimed to develop a sensitive and specific anti ...
Yusuke Sayama +6 more
doaj +1 more source
Regulated autocrine growth of CHO cells [PDF]
Cytotechnology, 2000 The goal of this work was to engineer a CHO cell line capable ofautocrine growth in a fully defined protein-free medium. Thiswas accomplished by stable integration of the genes encodinginsulin-like growth factor I (IGF-I) and transferrin into thegenome of a CHO-K1 cell line. Thelac operator/repressorsystem was used to regulate the expression of the IGF-
N A, Sunstrom +6 more
openaire +2 more sources
Towards Tumor Targeting via Invasive Assay Using Magnetospirillum magneticum
Frontiers in Microbiology, 2021 Magnetospirillum magneticum (AMB-1) are a species of magnetotactic bacteria (MTB) that are capable of orienting along the earth’s magnetic field lines through their organelles called magnetosomes.
Marvin Xavierselvan +4 more
doaj +1 more source
Separation of CHO cells using hydrocyclones [PDF]
Cytotechnology, 2007 Hydrocyclones are simple and robust separation devices with no moving parts. In the past few years, their use in animal cell separation has been proposed. In this work, the use of different hydrocyclone configurations for Chinese hamster ovary (CHO) cell separation was investigated following an experimental design.
Rodrigo C V, Pinto +2 more
openaire +2 more sources
Plasmodium vivax Gametocytes Adherence to Bone Marrow Endothelial Cells
Frontiers in Cellular and Infection Microbiology, 2021 In a Plasmodium vivax infection, it was shown a proportionally increased on gametocyte distribution within the bone marrow aspirant, suggesting a role of this organ as a reservoir for this parasite stage.
Luis Carlos Salazar Alvarez +17 more
doaj +1 more source
A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]
, 2016 Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I +2 more
core +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 Aim. In this study we aimed to develop the methodology to change the antigen specificity of chimeric antibodies by replacing the variable region genes in the previously designed universal plasmid constructions pLK DT-17 and pHG DT-17 encoding the DT-17 ...
T. G. Samartseva +5 more
doaj +1 more source