The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]
Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia+4 more
core +1 more source
Cell Detection in Domain Shift Problem Using Pseudo-Cell-Position Heatmap [PDF]
The domain shift problem is an important issue in automatic cell detection. A detection network trained with training data under a specific condition (source domain) may not work well in data under other conditions (target domain). We propose an unsupervised domain adaptation method for cell detection using the pseudo-cell-position heatmap, where a ...
arxiv
Modeling the Interference Generated from Car Base Stations towards Indoor Femto-cells [PDF]
In future wireless networks, a significant number of users will be vehicular. One promising solution to improve the capacity for these vehicular users is to employ moving relays or car base stations. The system forms cell inside the vehicle and then uses rooftop antenna for back-hauling to overcome the vehicular penetration loss.
arxiv +1 more source
Background Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficiency of this cell line such as ...
Fatemeh Safari, Bahman Akbari
doaj +1 more source
Effective Pseudo-Labeling based on Heatmap for Unsupervised Domain Adaptation in Cell Detection [PDF]
Cell detection is an important task in biomedical research. Recently, deep learning methods have made it possible to improve the performance of cell detection. However, a detection network trained with training data under a specific condition (source domain) may not work well on data under other conditions (target domains), which is called the domain ...
arxiv
Chinese hamster ovary (CHO) cells are the most common cell line used for the production of therapeutic proteins including monoclonal antibodies (mAbs). Host cell proteins (HCPs), secreted and released from lysed cells, accumulate extracellularly during ...
Jin Hyoung Park+5 more
semanticscholar +1 more source
On the Modeling and Analysis of Fast Conditional Handover for 5G-Advanced [PDF]
Conditional handover (CHO) is a state-of-the-art 3GPP handover mechanism used in 5G networks. Although it improves mobility robustness by reducing mobility failures, the decoupling of the handover preparation and execution phases in CHO significantly increases the signaling overhead.
arxiv
Investigation of the bystander effect in CHO-K1 cells [PDF]
Investigation of the bystander effect in Chinese Hamster Ovary cells (CHO-K1) co-cultured with cells irradiated in the dose range of 0.1-4 Gy of high LET 12C ions and X-rays.The radiobiological effects of charged heavy particles on a cellular or molecular level are of fundamental importance in the field of biomedical applications, especially in hadron ...
Dariusz Banaś+13 more
openaire +3 more sources
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Lysosomal replacement enzymes are essential therapeutic options for rare congenital lysosomal enzyme deficiencies, but enzymes in clinical use are only partially effective due to short circulatory half-life and inefficient biodistribution.
Weihua Tian+17 more
semanticscholar +1 more source
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric+4 more
core +3 more sources