Results 81 to 90 of about 11,449,307 (399)

Fucan effect on CHO cell proliferation and migration

Carbohydrate Polymers, 2013
Fucan is a term used to denominate sulfated L-fucose rich polysaccharides. Here, a heterofucan, named fucan B, was extracted from the Spatoglossum schröederi seaweed. This 21.5 kDa galactofucan inhibited CHO-K1 proliferation and migration when fibronectin was the substrate.
Célia Regina Cavichiolo Franco, Leonardo Thiago Duarte Barreto Nobre, Valquíria P. Medeiros, Arthur Anthunes Jacome Vidal, Ruth Medeiros Oliveira, Hugo Alexandre Oliveira Rocha, Jailma Almeida-Lima, Helena B. Nader, Edvaldo S. Trindade, Edgar J. Paredes-Gamero   +9 more
openaire   +3 more sources

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells [PDF]

, 2015
Iron overload coupled with low hepcidin levels are characteristics of hereditary haemochromatosis. To understand the role of transferrin receptor (TFR) and intracellular iron in hepcidin secretion, Chinese hamster ovary transferrin receptor variant (CHO ...
Bahr, Busbridge, Casey, Clark, D'Alessio, Derek Renshaw, Evans, Farnaud, Jacolot, Kanamori, Kosha Mehta, Kuvibidila, Livak, Maniatis, Mark Busbridge, McGraw, McKie, Mitla Garcia, Mosmann, Muckenthaler, Pamela Greenwell, Park, Pigeon, Pinnix, Preza, Pruitt, Riemer, Rosignoli, Schmidt, Sebastien Farnaud, Sevier, Truksa, Turkewitz, Vinood B. Patel, Wallace   +34 more
core   +2 more sources

Maximum entropy and population heterogeneity in continuous cell cultures [PDF]

, 2018
Continuous cultures of mammalian cells are complex systems displaying hallmark phenomena of nonlinear dynamics, such as multi-stability, hysteresis, as well as sharp transitions between different metabolic states. In this context mathematical models may suggest control strategies to steer the system towards desired states.
arxiv   +1 more source

Enhanced Mechanical Properties of Injectable Chitosan–Guar Gum Hydrogel Reinforced with Bacterial Cellulose Nanofibers for Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This study presents the development and characterization of injectable nanocomposite hydrogels based on N‐succinyl chitosan, oxidized guar gum, and bacterial cellulose nanofibers. Emphasizing enhanced mechanical properties and biocompatibility, the hydrogels exhibit fast gelation, improved structural integrity, and reduced swelling. Their potential for
Raimundo Nonato Fernandes Moreira Filho, Pascale Chevallier, Silvia Rodriguez Fernandez, Maud Viallon, Matheus Xavier de Oliveira, Ana Lorena de Brito Soares, Diego Mantovani, Judith Pessoa de Andrade Feitosa, Rodrigo Silveira Vieira   +8 more
wiley   +1 more source

Proteomic differences in recombinant CHO cells producing two similar antibody fragments

Biotechnology and Bioengineering, 2016
Chinese hamster ovary (CHO) cells are the most commonly used mammalian hosts for the production of biopharmaceuticals. To overcome unfavorable features of CHO cells, a lot of effort is put into cell engineering to improve phenotype.
W. Sommeregger, P. Mayrhofer, W. Steinfellner, D. Reinhart, M. Henry, M. Clynes, P. Meleady, R. Kunert   +7 more
semanticscholar   +1 more source

A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction. [PDF]

, 2016
BACKGROUND: Chinese Hamster Ovary (CHO) cells are the current industry standard for production of therapeutic monoclonal antibodies at commercial scales.
Marsh, D, Nesbeth, DN, Templar, A
core   +1 more source

Scalable Manufacturing of Radiation‐Tolerant Potentiometric Electrodes: A Systematic Transition from Laboratory to Semiautomated Fabrication

Advanced Engineering Materials, EarlyView.
Laboratory protocols for producing thin‐film pH electrodes for sterilized single‐use technologies have been successfully developed into a semiautomated workflow, with higher throughput and precision of membrane thickness. Accuracies are within 0.05 pH units versus ground truth, and uncertainty analysis reveals the largest sources of error to be derived
Bingyuan Zhao, Aiganym Yermembetova, Benson Kunhung Tsai, Jialong Huang, Alexander Wei   +4 more
wiley   +1 more source

Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway

Scientific Reports, 2015
Chinese hamster ovary (CHO) cells are the most widely used mammalian hosts for production of therapeutic proteins. However, development of recombinant CHO cell lines has been hampered by unstable and variable transgene expression caused by random ...
Jae Seong Lee, T. B. Kallehauge, L. Pedersen, H. F. Kildegaard   +3 more
semanticscholar   +1 more source

XNOR-VSH: A Valley-Spin Hall Effect-based Compact and Energy-Efficient Synaptic Crossbar Array for Binary Neural Networks [PDF]

arXiv, 2023
Binary neural networks (BNNs) have shown an immense promise for resource-constrained edge artificial intelligence (AI) platforms as their binarized weights and inputs can significantly reduce the compute, storage and communication costs. Several works have explored XNOR-based BNNs using SRAMs and nonvolatile memories (NVMs).
arxiv