Results 121 to 130 of about 79,213 (303)

DUCK‐Net: automated deep learning segmentation of ductular reactions in murine liver injury captures multicellular niche dynamics from H&E morphology

The Journal of Pathology, EarlyView.
Abstract Ductular reactions (DRs) are dynamic and complex multicellular responses that occur as a result of various hepatic injuries. Precise identification and quantification of the extent of DRs is a cornerstone of pre‐clinical modelling of liver disease, with links to inflammation, fibrosis, regeneration, and disease severity.
Nathalie Feeley, Kai Williams, Caitlin McCaffrey, Daniel Field, Kyle Davies, Hugh Warden, Luke Boulter, Steve Thorn, Tak Yung Man, Wei‐Yu Lu, Stephen J Wigmore, Ewen M Harrison, Stuart J Forbes, Ian P Tomlinson, Timothy J Kendall, Rachel V Guest   +15 more
wiley   +1 more source

Cholangiocarcinoma: a guide for the nonspecialist

, 2018
Munirah Alsaleh,1 Zoe Leftley,1 Thomas A Barbera,1 Paiboon Sithithaworn,2 Narong Khuntikeo,2 Watcharin Loilome,2 Puangrat Yongvanit,2 I Jane Cox,3 Nittaya Chamodol,2 Richard RA Syms,4 Ross H Andrews,1,2 Simon D Taylor-Robinson1 1Division of Surgery and ...
Alsaleh M, Yongvanit P, Cox IJ, Taylor-Robinson SD, Leftley Z, Loilome W, Andrews RH, Syms RRA, Khuntikeo N, Barbera TA, Sithithaworn P, Chamodol N   +11 more
core  

Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma

Heliyon
Previous studies have indicated the efficacy of momordin Ic (MIc), a plant-derived triterpenoid, against several types of cancers, implying its potential for further development.
Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunprai   +3 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Heterochronous Adrenal Metastasis from Intrahepatic Cholangiocarcinoma: Report of a Case

, 2014
We herein report a case of laparoscopic adrenalectomy for solitary adrenal metastasis from intrahepatic cholangiocarcinoma (ICC). Although the treatment of extrahepatic metastasis from primary liver tumors is essentially palliative, solitary metastasis ...
Adachi, Tomohiko, Maruya, Yasuhiro, Okamoto, Tatsuya, Kuroki, Tamotsu, Abe, Kuniko, Kanematsu, Takashi, Eguchi, Susumu   +6 more
core  

Emerging Therapies in Management of Cholangiocarcinoma

Cholangiocarcinoma is a heterogeneous group of biliary tract cancers that has a poor prognosis and globally increasing incidence and mortality. While surgical resection remains the only curative option for the treatment of cholangiocarcinoma, the ...
Veronica Rasmusen, Jessica Speckart, Zohray Talib, Dev A. GnanaDev, Amir A. Rahnemai-Azar   +4 more
core   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions

, 2018
Chara Stavraka,1,* Hannah Rush,1,* Paul Ross1,2 1Department of Medical Oncology, Guy’s Cancer, Guy’s & St Thomas’ NHS Foundation Trust, London, UK; 2Department of Oncology, King’s College Hospital NHS Foundation Trust, London,
Ross P, Rush H, Stavraka C
core  

A Rare Clinical Presentation of Cholangiocarcinoma

, 2017
Cholangiocarcinoma is an uncommon tumor, often diagnosed in the context of obstructive jaundice. Brain metastasis rarely occurs with the cerebellum being a rare site of spread of this type of tumor.
Elisa Gravito-Soares, Luis Tomé, Marta Gravito-Soares, Pedro Figueiredo   +3 more
core   +1 more source

Pathology of Cholangiocarcinoma and Combined Hepatocellular‐Cholangiocarcinoma [PDF]

Clinical Liver Disease, 2021
openaire   +2 more sources