Results 121 to 130 of about 96,828 (293)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Cholangiocarcinoma [PDF]

Visceral Medicine, 2016
Alfred, Königsrainer, Nisar P, Malek
openaire   +3 more sources

Transcriptome changes of liver fluke Opisthorchis viverrini in diabetic hamsters

Parasite
A recent study in hamsters showed that infection with the liver fluke Opisthorchis viverrini in diabetic hosts worsens the severity of hepatobiliary disease.
Chaidee Apisit, Charoenram Naruechar, Sengthong Chatchawan, Dangtakot Rungtiwa, Pinlaor Porntip, Pongking Thatsanapong, Pinlaor Somchai   +6 more
doaj   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Comparative Analysis of Four Matrix Dilution Methods for Eliminating IgM Paraprotein Interference in Prealbumin and Uric Acid Assays: Based on Two Case Reports

Journal of Clinical Laboratory Analysis, EarlyView.
IgM paraproteins can cause significant interference in prealbumin (PA) and uric acid (UA) measurements, leading to falsely abnormal results. We systematically compared four dilution methods to eliminate this interference. Dilution with the PA reagent (containing PEG) effectively restored accurate PA results.
Xiaowei Chi, Zihan Liu, Weifang Liu, Huihui Jiang, Denglu Zhang   +4 more
wiley   +1 more source

Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma

Heliyon
Previous studies have indicated the efficacy of momordin Ic (MIc), a plant-derived triterpenoid, against several types of cancers, implying its potential for further development.
Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunprai   +3 more
doaj   +1 more source

Association Between Multi‐Laboratory Parameters Pre‐ and Post‐Treatment and Pathological Features and Their Values in Clinical Decision in Primary Hepatic Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
Primary hepatic cancer (PHC), especially hepatocellular carcinoma (HCC), is still a significant burden worldwide. The efficacy of diagnosis, treatment response monitoring, and prognostication using laboratory biomarkers is still a challenge. This study analyzed multi‐laboratory parameters pre‐ and post‐treatment and their associations with clinical and
Xiaowei Chi, Weifang Liu, Zihan Liu, Jie Liu   +3 more
wiley   +1 more source

Differences in Right Hepatic Duct Length Among Left‐Sided Hepatectomies: Conventional Hepatectomy Versus Extended Hepatectomy Versus Trisectionectomy

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Left‐sided hepatectomy for perihilar cholangiocarcinoma includes conventional left hepatectomy (C‐LH; H1234‐B), extended left hepatectomy (E‐LH; H12345′8′‐B‐MHV), and left trisectionectomy (LT; H123458‐B). The anatomical characteristics of the resected length of the right hepatic duct (RHD) in E‐LH remain unclear.
Kota Sugiura, Mihoko Yamada, Takashi Mizuno, Shunsuke Onoe, Nobuyuki Watanabe, Shoji Kawakatsu, Junpei Yamaguchi, Masaki Sunagawa, Taisuke Baba, Tomoki Ebata   +9 more
wiley   +1 more source

Feasibility of Comprehensive Genomic Profiling for Biliary Tract Cancer Using Transpapillary Biopsy Samples: A Prospective Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Graphical summary of the study design, intervention, and outcomes. ABSTRACT Background Patients with biliary tract cancer (BTC) often have actionable mutations, and comprehensive genomic profiling (CGP) plays an important role. However, the feasibility of CGP using transpapillary biopsy (TPB) samples remains unclear.
Kazuya Miyamoto, Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Hirohumi Inoue, Ryosuke Sato, Akihiro Matsumi, Yuki Fujii, Daisuke Uchida, Motoyuki Otsuka   +9 more
wiley   +1 more source

Hospital Volume and Post‐Hepatectomy Liver Failure After Major Hepatectomy

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Post‐hepatectomy liver failure (PHLF) following major hepatectomy (MH) increases the risk of morbidity and death. The relationship between institutional MH volume, PHLF, and outcomes is not well characterized. Methods Adults undergoing MH from 2014 to 2021 in the ACS NSQIP hepatectomy‐targeted database were included.
Xane D. Peters, Brian C. Brajcich, Bona Ko, Catherine Valukas, Lauren M. Janczewski, Clifford Y. Ko, Ryan P. Merkow, Henry A. Pitt, David J. Bentrem   +8 more
wiley   +1 more source