Results 131 to 140 of about 71,405 (265)

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

Cancer Science, EarlyView.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu, Gang Yu, Yuan Liu, Yu Zhou, Wei Liu, Lin Wang, Lide Liu, Yan Liu, Tiejun Pan, Zhenyu Liu, Lei Gao   +10 more
wiley   +1 more source

Metabolic syndrome and the risk of cholangiocarcinoma: a hospital-based case–control study in China

, 2018
Jianping Xiong,1,* Xin Lu,1,* Weiyu Xu,1,* Yi Bai,1 Hanchun Huang,1 Jin Bian,1 Lei Zhang,1 Junyu Long,1 Yiyao Xu,2 Zhenjie Wang,2 Haitao Zhao1 1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and ...
Xiong J, Lu X, Long J, Huang H, Bian J, Zhang L, Bai Y, Xu W, Wang Z, Xu Y, Zhao H   +10 more
core  

Metallothionein overexpression and its prognostic relevance in intrahepatic cholangiocarcinoma and extrahepatic hilar cholangiocarcinoma (Klatskin tumors)

, 2009
Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and
Baba, Hideo Andreas, Schmitz, Klaus Jūrgen, Schmid, Kurt Werner, Kaiser, Gernot, Jasani, Bharat, Sotiropoulos, Georgios Charalambos, Lang, Hauke, Wohlschlaeger, Jeremias   +7 more
core   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Modulating Hallmarks of Cholangiocarcinoma

, 2018
How are cholangiocarcinoma cells different from non-malignant cholangiocytes? All of the hallmarks of cancer apply- those reported in this dissertation include cell proliferation, migration, apoptosis, and evasion of growth suppression.
Wehrkamp, Cody
core  

Five Advances in the Last 50 Years: Liver Malignancies

World Journal of Surgery, EarlyView.
Alex B. Blair, Timothy M. Pawlik
wiley   +1 more source

Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth via STING‐Mediated Type I Interferon Response in iCCA

Cancer Science, EarlyView.
Through bioinformatic analyses, iCCA cell models, and in vivo xenograft experiments, we show that autophagy inhibition sensitizes iCCA to MEK1/2 blockade by enhancing STING‐dependent type I interferon signaling. These findings support combined MEK1/2 and autophagy inhibition as a promising therapeutic strategy for iCCA. ABSTRACT The RAF–MEK–ERK pathway
Chengqiang Sun, Zheng Gao, Enfu Dong, Liangxia Ding, Shanru Feng, Jiafeng Chen, Pascal Kwangwari, Yinghong Shi, Weiren Liu, Xin Zhang, Ao Huang, Jian Zhou, Sheng Wang, Jia Fan, Xiutao Fu, ZhenBin Ding   +15 more
wiley   +1 more source

Claudin18.2 in extrahepatic cholangiocarcinoma: prevalence and insights into the immune milieu

reservedBackground. Biliary cancers are an extremely heterogeneous group of neoplasms affecting the biliary tree (cholangiocarcinomas: CCA) or the gallbladder (gallbladder cancer: GBC).
DEL FORNO, BIANCAMARIA
core  

The Top Five Advances in Solid Organ Transplantation in the Past Fifty Years

World Journal of Surgery, EarlyView.
Stephen J. Wigmore, Diana A. Wu
wiley   +1 more source

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, EarlyView.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source