Results 141 to 150 of about 89,075 (280)

Machine Learning‐Based Prediction of Life‐Threatening Complications During Hemodialysis in Hospitalized Patients With Poor General Conditions

Artificial Organs, EarlyView.
A machine learning model using predialysis data predicted sudden events during or after hemodialysis with high accuracy (auROC: 0.889). The key predictors included emergency hospitalization, recent surgery, high heart rate, low albumin levels, and high CRP.
Naotaka Kato, Takeshi Goto, Tomoyuki Ohira, Hirotaka Kinoshita, Kugo Kurokawa, Kouhei Naganuma, Chikako Ohminato, Junko Ogasawara, Shingo Hatakeyama, Yoshihiro Sasaki, Kazuyoshi Hirota, Chikara Ohyama   +11 more
wiley   +1 more source

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

Resveratrol as a Novel YAP Inhibitor Targeting Glioblastoma Progression and Sensitizing to Chemotherapy

Cancer Science, EarlyView.
This study shows that YAP, a key effector of the Hippo pathway, is highly upregulated in glioblastoma and drives tumor growth, invasion, and survival. Knockdown of YAP or treatment with Resveratrol (a blood–brain barrier–permeable phytochemical) significantly reduced these malignant traits.
Wannawat Khotchawan, Chanchao Lorthongpanich, Pakpoom Kheolamai, Sith Sathornsumetee, Surapol Issaragrisil   +4 more
wiley   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Perihilar Cholangiocarcinoma [PDF]

Mayo Clinic Proceedings, 2018
Meryl C, Nath, Michael S, Torbenson, Lori A, Erickson   +2 more
openaire   +2 more sources

Research Progress, Challenges, and Prospects of Primary Liver Cancer Organoids

Organ Medicine, EarlyView.
Zhenxiao Wang, Shui Liu
wiley   +1 more source

Aquaporin‐1 differentiates intrahepatic cholangiocarcinoma from liver metastases of pancreatic ductal adenocarcinoma

Histopathology, EarlyView.
Differentiating intrahepatic CCA from PDAC metastatic to the liver is critical for the clinical management of patients with pancreatobiliary cancers. AQP1 has demonstrated an excellent discriminatory performance in this clinical scenario. Aims Differentiating intrahepatic cholangiocarcinoma (iCCA) from metastatic ductal adenocarcinoma of the pancreas ...
Leoncini Giuseppe, Barella Marco, Droz Dit Busset Michele, Gentili Marco, Bodini Beatrice, Ronchetti Simona, Cari Luigi, Mazzaferro Vincenzo   +7 more
wiley   +1 more source

Endoscopic findings of gallbladder lesions evaluated with image‐enhanced endoscopy: A preliminary study using resected gallbladders

DEN Open, Volume 6, Issue 1, April 2026.
Abstract The diagnosis of gallbladder (GB) lesions relies on imaging findings. Transpapillary cholangioscopy can potentially be used to diagnose GB lesions; however, the images obtained remain unclear. This study aimed to characterize the endoscopic findings of GB lesions. We examined the endoscopic features of GB lesions in 50 consecutive patients who
Kiyoyuki Kobayashi, Maki Ayaki, Takako Nomura, Kaho Nakatani, Masaki Tokumo, Yasutaka Kokudo, Toshiaki Morito, Ichiro Ishikawa, Akihiro Kondo, Yasuhisa Ando, Hironobu Suto, Minoru Oshima, Ryota Nakabayashi, Toshiaki Kono, Naoki Fujita, Hiroki Yamana, Hideki Kamada, Masafumi Ono, Keiichi Okano, Hideki Kobara   +19 more
wiley   +1 more source

Standardized Approach for Laparoscopic Hemispheric Liver Resection for Segments 7 and 8

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background We investigated whether the standardized “can‐opener method” surgical technique is an adequate surgical procedure for hemispheric hepatectomy in segments 7 and 8. Methods Forty‐two patients who underwent laparoscopic hemispheric liver resection for segments 7 and 8 using our standardized surgical technique were enrolled.
Ryoichi Miyamoto, Masahiro Shiihara, Mitsuru Watanabe, Jiro Shimazaki, Mitsugi Shimoda, Shuji Suzuki   +5 more
wiley   +1 more source

Comparison of the Usefulness of Covered and Uncovered Laser‐cut Metal Stents

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives This study aimed to evaluate the clinical characteristics of laser‐cut self‐expandable metal stents (SEMS) and to compare the outcomes between covered and uncovered laser‐cut SEMS for malignant distal biliary obstruction (MDBO). Methods A multicenter retrospective analysis was conducted across eight Japanese university hospitals ...
Toshio Fujisawa, Masao Toki, Kei Saito, Yuta Hasegawa, Eisuke Iwasaki, Michihiro Saito, Katsuya Kitamura, Ryosuke Tonozuka, Takao Itoi, Ken Ito, Keiko Kaneko, Naminatsu Takahara, Tadakazu Hisamatsu, Hiroyuki Isayama   +13 more
wiley   +1 more source