Cancer Science, EarlyView.SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu +8 more
wiley +1 more source
Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria
Cancer Science, EarlyView.Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren +11 more
wiley +1 more source
, 1900 Cholangiocarcinoma. COMMENT: Diffuse involvement by tumor (Green = ""normal"" liver)--small areas of infarct also present ...
MUSC Department of Pathology and Laboratory Medicine
core
Correction: A blood test-based nomogram to predict the progression-free survival of patients with intrahepatic cholangiocarcinoma after surgical resection. [PDF]
Front OncolPeng L, Shi Y, Yang S, Li C.
europepmc +1 more source
Cancer Science, EarlyView.A customized panel was established for BTC MRD detection. Preoperative ctDNA detection was associated with pathological stage and poorer RFS and OS. Longitudinal monitoring detected ctDNA before radiological recurrence in 72.7% of patients, with a median lead time of 77 days, supporting ctDNA as a complementary prognostic biomarker with CA19‐9 ...
Yoshihito Shinohara +13 more
wiley +1 more source
Dietary Leucine Restriction Suppresses Platelet‐Driven HCC Growth by Attenuating mTOR Signaling
Cancer Science, EarlyView.Platelets induce leucine accumulation in HCC cells. In vitro, leucine deprivation or S6K1 inhibition with PF‐4708671 suppresses platelet‐promoted proliferation, migration, and invasion. In vivo, dietary leucine restriction reduces tumor growth following platelet pre‐incubation.
Xeulian Ruan +9 more
wiley +1 more source
Case Report: <i>Klebsiella pneumoniae</i>-associated pyogenic spondylitis and occult intrahepatic cholangiocarcinoma during calculous cholangitis. [PDF]
Front Med (Lausanne)Yang Z, Yan Y, Wang H, Zhou H, Zheng M.
europepmc +1 more source
GEVIS: A Workflow‐Driven Visual Analytics Approach to Differential Gene Expression Analysis
Computer Graphics Forum, EarlyView.Abstract Differential gene expression (DGE) analysis is one of the most widely used techniques for investigating RNA‐seq data and supports numerous medical and biological applications, including biomarker identification for diagnosis and prognosis, as well as the evaluation of medical treatments.
G. Blasilli +4 more
wiley +1 more source
Complete response in unresectable HER2+ cholangiocarcinoma with histotripsy and systemic therapy followed by liver transplantation: a case report. [PDF]
Front OncolJuarez TM +11 more
europepmc +1 more source
Liver Organoids: From Disease Modelling to Regenerative Medicine
Cell Proliferation, EarlyView.Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang +5 more
wiley +1 more source