Results 11 to 20 of about 27,028 (210)

Chemotherapeutic resistant cholangiocarcinoma displayed distinct intratumoral microbial composition and metabolic profiles [PDF]

PeerJ, 2022
Background Cholangiocarcinoma (CCA) is a malignancy of the cholangiocytes. One of the major issues regarding treatment for CCA patients is the development of chemotherapeutic resistance.
Sirinya Sitthirak, Manida Suksawat, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Sakkarn Sangkhamanon, Watcharin Loilome   +10 more
doaj   +2 more sources

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells [PDF]

PeerJ, 2023
Background Niclosamide is an oral anthelminthic drug that has been used for treating tapeworm infections. Its mechanism involves the disturbance of mitochondrial membrane potential that in turn inhibits oxidative phosphorylation leading to ATP depletion.
Thanaporn Kulthawatsiri, Yingpinyapat Kittirat, Jutarop Phetcharaburanin, Jittima Tomacha, Bundit Promraksa, Arporn Wangwiwatsin, Poramate Klanrit, Attapol Titapun, Watcharin Loilome, Nisana Namwat   +9 more
doaj   +2 more sources

1H NMR fecal metabolic phenotyping of periductal fibrosis- and cholangiocarcinoma-specific metabotypes defining perturbation in gut microbial-host co-metabolism [PDF]

PeerJ, 2023
Background The liver fluke Opisthorchis viverrini (OV), which subsequently inhabits the biliary system and results in periductal fibrosis (PDF), is one of the primarily causes of cholangiocarcinoma (CCA), a bile duct cancer with an exceptionally high ...
Rujikorn Treeriya, Phuc N. Ho, Attapol Titapun, Poramate Klanrit, Manida Suksawat, Thanaporn Kulthawatsiri, Suphasarang Sirirattanakul, Watcharin Loilome, Nisana Namwat, Arporn Wangwiwatsin, Nittaya Chamadol, Narong Khuntikeo, Jutarop Phetcharaburanin   +12 more
doaj   +2 more sources

Modification of the eighth AJCC/UICC staging system for perihilar cholangiocarcinoma: An alternative pathological staging system from cholangiocarcinoma-prevalent Northeast Thailand

Frontiers in Medicine, 2022
AimThis study aims to improve the classification performance of the eighth American Joint Committee on Cancer (AJCC) staging system for perihilar cholangiocarcinoma (pCCA) by proposing the Khon Kaen University (KKU) staging system developed in ...
Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Prakasit Sa-Ngiamwibool, Prakasit Sa-Ngiamwibool, Prakasit Sa-Ngiamwibool, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Piyapharom Intarawichian, Piyapharom Intarawichian, Waritta Kunprom, Waritta Kunprom, Waritta Kunprom, Malinee Thanee, Malinee Thanee, Malinee Thanee, Piya Prajumwongs, Piya Prajumwongs, Piya Prajumwongs, Narong Khuntikeo, Narong Khuntikeo, Narong Khuntikeo, Attapol Titapun, Attapol Titapun, Attapol Titapun, Apiwat Jareanrat, Apiwat Jareanrat, Apiwat Jareanrat, Vasin Thanasukarn, Vasin Thanasukarn, Vasin Thanasukarn, Tharatip Srisuk, Tharatip Srisuk, Tharatip Srisuk, Vor Luvira, Vor Luvira, Vor Luvira, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Julaluck Promsorn, Julaluck Promsorn, Julaluck Promsorn, Watcharin Loilome, Watcharin Loilome, Watcharin Loilome, Aileen Wee, Supinda Koonmee, Supinda Koonmee, Supinda Koonmee   +51 more
doaj   +1 more source

Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models

Cancer & Metabolism, 2021
Background Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no effective chemotherapy.
Malinee Thanee, Sureerat Padthaisong, Manida Suksawat, Hasaya Dokduang, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Arporn Wangwiwatsin, Prakasit Sa-ngiamwibool, Narong Khuntikeo, Hideyuki Saya, Watcharin Loilome   +12 more
doaj   +1 more source

Prognostic significance of tumor-infiltrating lymphocytes in predicting outcome of distal cholangiocarcinoma in Thailand

Frontiers in Oncology, 2022
Patients with distal cholangiocarcinoma (dCCA) generally have poor outcomes because of late presentation and diagnosis. Therefore, prognostic factors for predicting outcomes are essential to improve therapeutic strategies and quality of life.
Piyapharom Intarawichian, Piyapharom Intarawichian, Piyapharom Intarawichian, Sirada Sangpaibool, Sirada Sangpaibool, Sirada Sangpaibool, Piya Prajumwongs, Piya Prajumwongs, Piya Prajumwongs, Prakasit Sa-Ngiamwibool, Prakasit Sa-Ngiamwibool, Prakasit Sa-Ngiamwibool, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Waritta Kunprom, Waritta Kunprom, Waritta Kunprom, Malinee Thanee, Malinee Thanee, Malinee Thanee, Watcharin Loilome, Watcharin Loilome, Watcharin Loilome, Narong Khuntikeo, Narong Khuntikeo, Narong Khuntikeo, Attapol Titapun, Attapol Titapun, Attapol Titapun, Apiwat Jareanrat, Apiwat Jareanrat, Apiwat Jareanrat, Vasin Thanasukarn, Vasin Thanasukarn, Vasin Thanasukarn, Tharatip Srisuk, Tharatip Srisuk, Tharatip Srisuk, Vor Luvira, Vor Luvira, Vor Luvira, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Julaluck Promsorn, Julaluck Promsorn, Julaluck Promsorn, Supinda Koonmee, Supinda Koonmee, Supinda Koonmee, Aileen Wee, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri   +54 more
doaj   +1 more source

Validation of pencil beam scanning proton therapy with multi‐leaf collimator calculated by a commercial Monte Carlo dose engine

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract This study aimed to evaluate the clinical beam commissioning results and lateral penumbra characteristics of our new pencil beam scanning (PBS) proton therapy using a multi‐leaf collimator (MLC) calculated by use of a commercial Monte Carlo dose engine.
Yuki Tominaga, Yusuke Sakurai, Junya Miyata, Shuichi Harada, Takashi Akagi, Masataka Oita   +5 more
wiley   +1 more source

Accuracy of a new rapid diagnostic test for urinary antigen detection and assessment of drug treatment in opisthorchiasis

Infectious Diseases of Poverty, 2023
Background Screening for opisthorchiasis, a parasitic worm infection affecting many millions of people in Southeast Asia, has traditionally relied on faecal egg examination such as the formalin-ethyl acetate concentration technique (FECT) and Kato-Katz ...
Chanika Worasith, Jiraporn Sithithaworn, Phattharaphon Wongphutorn, Chutima Homwong, Kanoknan Khongsukwiwat, Anchalee Techasen, Kulthida Y. Kopolrat, Watcharin Loilome, Nisana Namwat, Bandit Thinkamrop, Chaiwat Tawarungruang, Attapol Titapun, Thewarach Laha, Ross H. Andrews, Simon D. Taylor-Robinson, Paiboon Sithithaworn   +15 more
doaj   +1 more source

Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand

Frontiers in Public Health, 2022
Distal cholangiocarcinoma (dCCA) is a rare type of CCA in Asia, even in Opisthorchis viverrini-prevalent Northeastern Thailand. The clinical ambiguity and imprecision of diagnosis surrounding this malignancy result in high mortality due often to advanced/
Waritta Kunprom, Waritta Kunprom, Waritta Kunprom, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Piyapharom Intarawichian, Piyapharom Intarawichian, Walailak Bamrungkit, Walailak Bamrungkit, Walailak Bamrungkit, Malinee Thanee, Malinee Thanee, Malinee Thanee, Piya Prajumwongs, Piya Prajumwongs, Piya Prajumwongs, Watcharin Loilome, Watcharin Loilome, Watcharin Loilome, Narong Khuntikeo, Narong Khuntikeo, Narong Khuntikeo, Attapol Titapun, Attapol Titapun, Attapol Titapun, Apiwat Jareanrat, Apiwat Jareanrat, Apiwat Jareanrat, Vasin Thanasukarn, Vasin Thanasukarn, Vasin Thanasukarn, Tharatip Srisuk, Tharatip Srisuk, Tharatip Srisuk, Vor Luvira, Vor Luvira, Vor Luvira, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Kulyada Eurboonyanun, Julaluck Promsorn, Julaluck Promsorn, Julaluck Promsorn, Supinda Koonmee, Supinda Koonmee, Supinda Koonmee   +53 more
doaj   +1 more source

The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand

Frontiers in Public Health, 2022
Cholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and
Supinda Koonmee, Supinda Koonmee, Supinda Koonmee, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Sakkarn Sangkhamanon, Piyapharom Intarawichian, Piyapharom Intarawichian, Piyapharom Intarawichian, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Chaiwat Aphivatanasiri, Waritta Kunprom, Waritta Kunprom, Waritta Kunprom, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Prakasit Sa-ngiamwibool, Suwit Balthaisong, Suwit Balthaisong, Suwit Balthaisong, Chitsakul Phuyao, Chitsakul Phuyao, Chitsakul Phuyao, Piya Prajumwongs, Piya Prajumwongs, Piya Prajumwongs, Reza Alaghehbandan, Malinee Thanee, Malinee Thanee, Malinee Thanee   +30 more
doaj   +1 more source