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Cholangiopathies and the noncoding revolution

Current Opinion in Gastroenterology, 2022
Purpose of review Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) among others, have attracted a great deal of attention for their potential role as master regulators of gene expression and as therapeutic targets.
Sergio, Gradilone   +2 more
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Pathophysiology of Cholangiopathies

Journal of Clinical Gastroenterology, 2005
The diseases of the intrahepatic biliary tree are a large group of potentially evolutive congenital and acquired liver disorders affecting both the adult and pediatric populations. They represent a relevant cause of liver-related morbidity and mortality and an important indication for liver transplantation, particularly in children. While the practical
STRAZZABOSCO M, FABRIS, LUCA, SPIRLI C.
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Ischemic cholangiopathy

Journal of Hepatology, 2006
Bile ducts are supplied with blood exclusively via hepatic arteries. Obstruction of large arteries is rapidly compensated for by the opening of preexisting intrahepatic or transcapsular collateral arteries, which prevents ischemic damage. Ischemic bile duct injury may occur when small hepatic arteries or the peribiliary vascular plexus are injured, or ...
Deltenre, Pierre   +1 more
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The Intrahepatic Cholangiopathies

Seminars in Liver Disease, 1998
The intrahepatic biliary epithelial cells or cholangiocytes are the primary focus of injury in many congenital and acquired liver diseases of childhood. Although cholangiocytes account for only 3 to 5% of the liver cell population, injury and progressive loss of intrahepatic bile ducts can result in considerable morbidity and mortality.
A, Birnbaum, F J, Suchy
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AIDS cholangiopathy

Current Treatment Options in Gastroenterology, 2004
AIDS is an advanced disease with systemic and infectious complications that can be fatal. When a patient with AIDS presents with right upper quadrant or midepigastric pain, cholestasis, and symptoms of cholangitis, AIDS cholangiopathy should be suspected and appropriate diagnostic and therapeutic interventions should be initiated.
Tony E., Yusuf, Todd H., Baron
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AUTOIMMUNE CHOLANGIOPATHY

Clinics in Liver Disease, 1999
Currently available evidence is insufficient to classify PBC and AIC as separate diseases. The ultimate answer to the question of whether AIC, defined as AMA-negative PBC with ANA or SMA, is a disease distinct from AMA-positive PBC with or without ANA will require a detailed comparison of etiologic factors and pathogenetic mechanisms, once they are ...
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Infantile Obstructive Cholangiopathy

Archives of Pediatrics & Adolescent Medicine, 1979
The relationship between neonatal hepatitis and biliary atresia has been extensively discussed. Clinical and laboratory evaluations are often unsuccessful in distinguishing between the two diseases. Laparotomy, cholangiogram, and liver biopsy are often required.
P J, McDonald   +2 more
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The cholangiopathies: Disorders of biliary epithelia

Gastroenterology, 2004
The intrahepatic bile ducts comprise a complex 3-dimensional network of conduits within the liver lined by specialized epithelial cells called cholangiocytes. A majorfunction of cholangiocytes is bile formation (Figure 1). Hepatocytes, the other epithelial cell type of the liver, produce primary or hepatic bile, which percolates through the ...
Lazaridis, KN   +2 more
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Ketamine-induced cholangiopathy

Ugeskrift for Læger
A 26-year-old male with chronic ketamine use was admitted with abdominal pain and elevated infection numbers, and liver-function tests. An ultrasound of the upper abdomen showed a dilated common bile duct with no sign of gallbladder stones. A subsequent magnetic resonance cholangiopancreatography and endoscopic ultrasound found no explanation for the ...
Maria, Høybye   +2 more
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AIDS cholangiopathy.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 1998
A 45-year-old man presented with diarrhea and profound weight loss over one year. His serum alkaline phosphatase was raised and ultrasonography showed dilated intrahepatic biliary ducts and upper part of common bile duct (CBD). ERCP showed papillary stenosis, dilated CBD, stricture at the confluence and saccular dilatation of the left intrahepatic ...
A, Misra   +3 more
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