Results 1 to 10 of about 83,265 (304)
The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease. [PDF]
Clin Pharmacol Drug DevAbstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Rolan P +7 more
europepmc +2 more sources
Optimal hepatobiliary scintigraphy for gallbladder dyskinesia
Surgery Open Science, 2021 Background: The accuracy of hepatobiliary scintigraphy to assess gallbladder function remains controversial. National supply shortages of pharmaceutical-grade cholecystokinin led to the use of an oral fatty meal to stimulate gallbladder contraction ...
K.F. Flick, MD +6 more
doaj +1 more source
Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle
Cells, 2022 Recent studies have highlighted the importance of autophagy and particularly non-canonical autophagy in the development and progression of acute pancreatitis (a frequent disease with considerable morbidity and significant mortality).
Svetlana Voronina +6 more
doaj +1 more source
Сучасна педіатрія: Україна, 2023 So far, the possible influence of single nucleotide variants (SNV) of the cholecystokinin (CCK) gene on the likelihood of developing obesity and metabolic disorders in children has not been demonstrated.
A. Nikulina
doaj +1 more source
Administration of encapsulated L-tryptophan improves duodenal starch digestion and increases gastrointestinal hormones secretions in beef cattle [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective This study investigated the effects of oral administration of rumen-protected L-tryptophan (RPL-T) on duodenal starch digestion and gastrointestinal hormones (GIH) secretions using Hanwoo beef steers as the animal models.
Sang-Bum Lee +9 more
doaj +1 more source
A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
eLife, 2021 Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks.
Shankar Ramachandran +11 more
doaj +1 more source
Frontiers in Neural Circuits, 2022 Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date,
Sanne M. Casello +9 more
doaj +1 more source
Sacubitril/valsartan increases postprandial gastrin and cholecystokinin in plasma
Endocrine Connections, 2020 Aims: Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of
Ulrik Ø Andersen +7 more
doaj +1 more source
European Psychiatry, 2022 Introduction The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily.
O. Dorofeeva +3 more
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Biomolecules, 2020 Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska +1 more
doaj +1 more source