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Carbohydrate inhibitors of cholera toxin [PDF]
Beilstein Journal of Organic Chemistry, 2018 Cholera is a diarrheal disease caused by a protein toxin released by Vibrio cholera in the host’s intestine. The toxin enters intestinal epithelial cells after binding to specific carbohydrates on the cell surface.
Vajinder Kumar, W. Bruce Turnbull
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Advances in phage display based nano immunosensors for cholera toxin [PDF]
Frontiers in Immunology, 2023 Cholera, a persistent global public health concern, continues to cause outbreaks in approximately 30 countries and territories this year. The imperative to safeguard water sources and food from Vibrio cholerae, the causative pathogen, remains urgent. The
Yang Li +4 more
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Administration of novobiocin and apomorphine mitigates cholera toxin mediated cellular toxicity: Lessons from cholera toxin yeast model system. [PDF]
PLoS ONECholera is a dreadful disease. The scourge of this deadly disease is still evident in the developing world. Though several therapeutic strategies are in practice to combat and contain the disease, there is still a need for new drugs to control the ...
Sonali Eknath Bhalerao +2 more
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Studies on Cholera Toxin and Antitoxin [PDF]
Journal of General Microbiology, 1970 SUMMARY: The preparation, purification and properties of cholera toxin type 2 are described. When the toxin was given to experimental animals it induced a high level of toxin-neutralizing antibodies. Cholera toxoid given to human volunteers induced antibodies consisting of agglutinins, vibriocidal and toxin-neutralizing antibodies.
J. Ungar +3 more
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Cholera toxin phage: structural and functional diversity between Vibrio cholerae biotypes [PDF]
AIMS Microbiology, 2020 Cholera is a severe form of watery diarrhea caused by Vibrio cholerae toxigenic strains. Typically, the toxigenic variants of V. cholerae harbor a bacteriophage, cholera toxin phage, integrated in their genome.
Ashrafus Safa +2 more
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Cholera Toxin as a Probe for Membrane Biology. [PDF]
Toxins (Basel), 2021 Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in membrane biology and biophysics. CTxB is a homopentameric stable protein that binds tightly to up to five GM1 glycosphingolipids. This provides a robust and tractable model for exploring membrane structure and its dynamics including vesicular trafficking and ...
Kenworthy AK +6 more
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Vibrio mimicus Lineage Carrying Cholera Toxin and Vibrio Pathogenicity Island, United States and China [PDF]
Emerging Infectious DiseasesVibrio mimicus bacteria have caused sporadic cases and outbreaks of cholera-like diarrhea throughout the world, but the association of lineages with such events is unexplored. Genomic analyses revealed V.
Sergio Mascarenhas Morgado +3 more
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Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. [PDF]
PLoS Neglected Tropical Diseases, 2018 Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance.
Soumita Das +7 more
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The Role of Vesicles in Transporting of Cholera Toxin
Проблемы особо опасных инфекций, 2023 The review reports on the secretion pathways of the main virulence factor of Vibrio cholerae, cholera toxin, both through the two-stage Sec-dependent type 2 secretion system and with the help of vesicles of the outer membrane of V. cholerae.
V. P. Zyuzina +4 more
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Проблемы особо опасных инфекций, 2022 A marker of the epidemic significance of Vibrio cholerae is their toxigenicity. Therefore, much attention is currently paid to the creation of diagnostic preparations for the detection of cholera toxin and assessment of the level of its production.
L. V. Larionova +4 more
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