Results 91 to 100 of about 77,443 (276)

Corticotropin‐releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress‐induced visceral sensory signals to the brain

Journal of Neuroendocrinology, EarlyView.
Corticotropin‐releasing factor (CRF) and its type 1 receptor (CRF1) are expressed in the rat colon. The vagal nodose ganglion transmits visceral information to the brain; but whether the CRF/CRF1 system is involved in vagal afferent function remains unknown.
Asuka Mano‐Otagiri, Tamotsu Shibasaki, Atsushi Sakai, Yoshihiko Kakinuma   +3 more
wiley   +1 more source

The influence of the accessory genome on bacterial pathogen evolution [PDF]

, 2011
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity.
Abu-Ali GS, Adiba S, Alfano JR, Arnold DL, Arnold DL, Arnold DL, Asadulghani M, Baharoglu Z, Baquero F, Barash I, Blondel CJ, Blondel CJ, Brüssow H, Cambray G, Chen J, Chen Y, Choi J, Colinon C, Croucher NJ, Dawes FE, De Gelder L, Diard M, Dillon SC, Douard G, Doyle M, Elsaied H, Fondi M, Freeman VJ, Gartemann KH, Gillings MR, Godfrey SAC, Govind R, Greenberg JT, Grillot-Courvalin C, Groisman EA, Guerin E, Hacker J, Hacker J, Halary S, Hassan F, Hazen TH, Hegstad K, Heinemann JA, Heringa S, Hochhut B, Holden MT, Huang L, Imamovic L, Jackson RW, Jackson RW, Jenner C, Joss M, Jové T, Kearney B, Kers JA, Kiiru JN, Koenig JE, Koenig JE, Krauland MG, Landgraf A, Larsson P, Leplae Rl, León G, Lipps HJ, Lloyd AL, Loftie-Eaton W, Lovell HC, Lovell HC, Manning SD, Marchetti M, Matz C, Maurelli AT, Mazel D, Michael CA, Michael CA, Morris CE, Morris CE, Moura A, Naas T, Nadarasah G, Naka H, Nawaz M, Ogura Y, Paauw A, Partridge SR, Pitman A, Poirel L, Poirel L, Ramirez MS, Rankin DJ, Rezzonico F, Rivas LA, Rodriguez-Martinez JM, Rohmer L, Rosewarne CP, Sajjad A, Salanoubat M, Salzberg SL, Seth-Smith H, Shaheen BW, Siguier P, Siguier P, Smillie C, Smith AB, Song H, Sota M, Steinberg KM, Sundin GW, Sundin GW, Tao L, Treangen TJ, van der Meer JR, van der Veen EL, van Essen-Zandbergen A, Wagner A, Waldor MK, Wiesner M, Woodford N, Yang H, Zhou Z, Zupan J   +120 more
core   +2 more sources

Developing downstream processes for the purification of recombinant proteins and small molecules from Nicotiana benthamiana biomass

Plant Biotechnology Journal, EarlyView.
Summary Nicotiana benthamiana (Australian tobacco) has become a major host for plant‐based recombinant protein production, especially using transient expression. Once a candidate protein has been designed and produced in a suitable variety (e.g. facilitated humanized glycosylation) under reproducible conditions (e.g.
J. F. Buyel
wiley   +1 more source

The Major Soybean Allergen Gly m Bd 28K Induces Hypersensitivity Reactions in Mice Sensitized to Cow's Milk Proteins [PDF]

, 2016
Reactions to soy have been reported in a proportion of patients with IgE-mediated cow’s milk allergy (CMA). In this work, we analyzed if Gly m Bd 28K/P28, one of the major soybean allergens, is a cross-reactive allergen with cow milk proteins (CMP).
Candreva, Ángela María, Curciarello, Renata, Docena, Guillermo H., Fossati, Carlos Alberto, Petruccelli, Silvana, Smaldini, Paola Lorena   +5 more
core   +2 more sources

The Apoptotic Effects of the P300 Activator on Breast Cancer and Lung Fibroblast Cell Lines

Middle East Journal of Cancer, 2013
Background: P300 is an enzyme that acetylates histones during stress. It alsoacetylates several non-histone proteins, including P53 which is the most important tumorsuppressor gene. P53 plays an important role in the apoptosis of tumor cells. Hereby,this
Mohammad Reza Salahshoor, Cyrus Jalili, Ahmad Shebanizadeh Darehdori, Mozafar Khazaei, Shiva Roshankhah, Rostam Ghorbani   +5 more
doaj  

Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for SARS‐CoV‐2 Expressed in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mucosal vaccination for COVID‐19 to boost preexisting though insufficient systemic and local/mucosal immunity remains an attractive prospect but there are currently no licensed mucosal vaccines against this infection. Here, using a plant expression system, we developed a novel mucosal vaccine platform for respiratory viruses and demonstrated ...
Mi‐Young Kim, Andy Cano Tran, Ju Kim, Humblenoble Stembridge Ayuk, Adam Sparrow, Lorenzo Bossi, Megan Brown, Emil Joseph Vergara, Kathrin Göritzer, Elisabetta Groppelli, Tae‐Ho Kwon, Julian K. C. Ma, Yong‐Suk Jang, Rajko Reljic   +13 more
wiley   +1 more source

Association between post-diagnostic use of cholera vaccine and risk of death in prostate cancer patients

Nature Communications, 2018
Post-diagnostic use of cholera vaccine can improve the prognosis in patients with colorectal cancer suggesting cholera toxin might have an antineoplastic effect.
Jianguang Ji, Jan Sundquist, Kristina Sundquist   +2 more
doaj   +1 more source

Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae

mSphere, 2019
Vibrio cholerae infection provides long-lasting protective immunity, while oral, inactivated cholera vaccines (OCV) result in more-limited protection. To identify characteristics of the innate immune response that may distinguish natural V.
Ana A. Weil, Crystal N. Ellis, Meti D. Debela, Taufiqur R. Bhuiyan, Rasheduzzaman Rashu, Daniel L. Bourque, Ashraful I. Khan, Fahima Chowdhury, Regina C. LaRocque, Richelle C. Charles, Edward T. Ryan, Stephen B. Calderwood, Firdausi Qadri, Jason B. Harris   +13 more
doaj   +1 more source

Cholera toxin: Vibrio cholera's dehydration machine

The FASEB Journal, 2012
The Blue Valley Center for Advanced Professional Studies (BVCAPS) SMART Team members researched the actions of the microbe Vibrio cholera in causing the water born disease cholera, which infects millions of humans annually and causes death to thousands of individuals through extreme fluid loss.
R. Pohl, Douglas L. Mann, J. Long, A. Taghizadeh, K. Strombom, A. Rice, K. Pedersen, G. Wehemyer, K. O’Leary, N. Larson, N. Hron, J. Hermanson, V. Menon, A. Fehr, J. Whalen, G. Mohar, R. McLean, A. Rottinghaus, J. Hsu, V. Nguyen, T. Schaefer, K. Bannerman, T. Scott, T. Rodriguez, E. Kessler, F. Moret, G. Long, B. Whitcomb, H. Reynolds, J. Vollick, D. Assyia, C. Anderson   +31 more
openaire   +2 more sources

Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

Experimental Physiology, EarlyView.
Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels, which ...
Gregory J. Ordemann, Polina Lyuboslavsky, Alena Kizimenko, Audrey C. Brumback   +3 more
wiley   +1 more source