Results 11 to 20 of about 77,065 (293)

Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2018
Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance.
Soumita Das   +7 more
doaj   +7 more sources

Studies on Cholera Toxin and Antitoxin [PDF]

open access: bronzeJournal of General Microbiology, 1970
SUMMARY: The preparation, purification and properties of cholera toxin type 2 are described. When the toxin was given to experimental animals it induced a high level of toxin-neutralizing antibodies. Cholera toxoid given to human volunteers induced antibodies consisting of agglutinins, vibriocidal and toxin-neutralizing antibodies.
J. Ungar   +3 more
openalex   +4 more sources

Cholera Toxin as a Probe for Membrane Biology. [PDF]

open access: yesToxins (Basel), 2021
Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in membrane biology and biophysics. CTxB is a homopentameric stable protein that binds tightly to up to five GM1 glycosphingolipids. This provides a robust and tractable model for exploring membrane structure and its dynamics including vesicular trafficking and ...
Kenworthy AK   +6 more
europepmc   +6 more sources

p97 Is in a Complex with Cholera Toxin and Influences the Transport of Cholera Toxin and Related Toxins to the Cytoplasm [PDF]

open access: yesJournal of Biological Chemistry, 2005
Certain protein toxins, including cholera toxin, ricin, and Pseudomonas aeruginosa exotoxin A, are transported to the lumen of the endoplasmic reticulum where they retro-translocate across the endoplasmic reticulum membrane to enter the cytoplasm.
Rockford K. Draper   +3 more
openaire   +2 more sources

Vibrio cholerae Infection of Drosophilamelanogaster Mimics the Human Disease Cholera.

open access: yesPLoS Pathogens, 2005
Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world.
Nathan S Blow   +6 more
doaj   +2 more sources

OBTAINING OF MONOCLONAL ANTIBODIES AGAINST CHOLERA TOXIN AND HEAT LABILE ENTEROTOXIN OF E. coli FOR DEVELOPMENT OF THE TOXINS DIPLEX ANALYSIS IN ENVIRONMENTAL SPECIMENS [PDF]

open access: yesBiotechnologia Acta, 2013
The present study focuses on development of monoclonal antibodies (MAbs) which specifically interact with cholera toxin or heat labile enterotoxin of E. coli.
Eu. V. Grishin, T. I. Valiakina
doaj   +1 more source

Chloroquine inhibition of cholera toxin [PDF]

open access: yesFEBS Letters, 1990
Cholera toxin (CT) stimulated adenylate cyclase and a phospholipase which elevated levels of 3.5‐cyclic adenosine monophosphate (cAMP) and arachidonic acid (AA). The AA was quickly converted to prostaglandins (PGs) via the cyclo‐oxygenase pathway. Chloroquine exerted minimal inhibition of cAMP levels in CT‐treated cells, although CT‐induced release of [
Johnny W. Peterson   +3 more
openaire   +3 more sources

Cholera toxin A1 residues single alanine substitutional mutation and effect on activity with stimulatory G protein

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2017
Cholera is a well-known gastrointestinal infection. The cholera toxin is an important pathological substance in pathogenesis of cholera diarrhea. Cholera toxin is composed of catalytic A1 subunit, an A2 linker, and a homopentameric cell-binding B subunit.
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source

Cholera toxin [PDF]

open access: yesBioscience Reports, 1977
Summary1. Death in several infectious diseases is caused by protein toxins secreted by invading bacteria. Cholera toxin is a simple protein secreted by Vibrio cholerae colonizing the gut; it is responsible for the massive diarrhoea that is cholera.2. The primary action of cholera toxin is an activation of adenylate cyclase, an enzyme found on the inner
openaire   +3 more sources

Neutralization of cholera toxin by Rosaceae family plant extracts

open access: yesBMC Complementary and Alternative Medicine, 2019
Background Cholera is one of the most deadly diarrheal diseases that require new treatments. We investigated the neutralization of cholera toxin by five plant extracts obtained from the Rosaceae family that have been traditionally used in Poland to treat
Magdalena Komiazyk   +4 more
doaj   +1 more source

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