Results 51 to 60 of about 77,443 (276)

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Advances in enteric disease vaccines: from innovation to implementation [PDF]

, 2014
The Seventh International Conference on Vaccines for Enteric Diseases Bangkok, Thailand, 6–8 November 2013 Hosting 222 participants from more than 25 countries, the Seventh International Conference on Vaccines for Enteric Diseases (VED 2013) displayed ...
Parker, EPK
core   +1 more source

Role of Vibrio cholerae neuraminidase in the function of cholera toxin [PDF]

Infection and Immunity, 1992
Vibrio cholerae neuraminidase (NANase) is hypothesized to act synergistically with cholera toxin (CT) and increase the severity of a secretory response by increasing the binding and penetration of CT to enterocytes. To test this hypothesis, the NANase gene (nanH) from V. cholerae Ogawa 395 was first cloned and sequenced.
Alessio Fasano, Steven S. Wasserman, Julian M. Ketley, S H Richardson, J B Kaper, James E. Galen   +5 more
openaire   +3 more sources

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

Advanced Science, EarlyView.
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel, Anna Kotowska, Zhimeng Fan, Ellen Juel Portner, Catherine Merry, Pontus Nordenfelt, Adam Cohen Simonsen, Amanda J. Wright, Vinay S Swaminathan   +8 more
wiley   +1 more source

The adenylate cyclase receptor complex and aqueous humor formation. [PDF]

, 1984
The secretory tissue of the eye, the ciliary processes, contains an enzyme receptor complex, composed of membrane proteins, the catalytic moiety of the enzyme adenylate cyclase, a guanyl nucleotide regulatory protein (or N protein), and other features ...
Caprioli, J, Sears, M
core   +1 more source

Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells.

PLoS ONE, 2021
Infectious gastrointestinal diseases are frequently caused by toxins secreted by pathogens which may impair physiological functions of the intestines, for instance by cholera toxin or by heat-labile enterotoxin.
Pascal Hoffmann, Marion Burmester, Marion Langeheine, Ralph Brehm, Michael T Empl, Bettina Seeger, Gerhard Breves   +6 more
doaj   +1 more source

CDK4/6 Inhibitor Priming Enhances PD‐1 Blockade via Sellhi Neutrophil‐Induced Stat5a+ Progenitor Exhausted CD8+ T Cell

Advanced Science, EarlyView.
Activated tumor‐intrinsic cyclin D1‐CDK4/6 signaling attenuates lymphocyte infiltration, and consequently, and immunotherapy resistance in HNSCC. It is discovered that brief CDK4/6i priming before anti‐PD‐1 results in enhanced durability of ICB response durability through Stat5a+ progenitor exhausted CD8+ T cells induced by IL15‐secreted Sell(hi ...
Yu Zhang, Bao Sun, Rong Zhou, Zizhen Gong, Yong Han, Wenjie Tao, Chaoji Shi, Wuchang Zhang, Laikui Liu, Zhiyuan Zhang, Jiang Li, Qi Zhu, Weiwen Zhu, Ziyue Gu   +13 more
wiley   +1 more source

Construction of an El Tor Biovariant Vibrio cholerae Strain Capable of Type II Cholera Toxin Hyperproduction and Determining the Optimal Conditions for the Production of This Protein

Проблемы особо опасных инфекций, 2008
Introduction of Tn5-Mob (KmR) transposon into the chromosome of the toxinogenic V. cholerae strain MAK757 El Tor biovar was shown to result in the emergence of insertion mutants containing an altered genome of CTXφ prophage.
A. A. Goryaev, E. Yu. Shchelkanova, Yu. V. Lozovsky, I. V. Touchkov, N. I. Smirnova   +4 more
doaj   +1 more source

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen, Jiajia Zhang, Junhan Ou, Ziheng Bai, Tongyan Liu, Kaiyue Zhang, Kaixiang Zhu, James Q. Wang, Chaochen Wang, Qianting Zhang, Linrong Lu, Wenwen Huang   +11 more
wiley   +1 more source

A Two‐Stage Cascading Amplification Strategy Based on Zn2+‐Doped WOX Nanozymes for Ultrasensitive Lateral Flow Immunoassays of Clostridium Difficile Toxin B

Advanced Science, EarlyView.
Based on the modulation of active sites and electronic structure of substrate materials, along with a colorimetric two‐stage cascading enhancement strategy, an LFIA platform with highly efficient POD‐mimetic enzymes is developed, achieving highly sensitive detection of Clostridium difficile toxin B.
Junhua Su, Zhenzhen Liu, Renjie Xiong, Renlong zhu, Zijin Tong, Yufei Liu, Rui Xiao   +6 more
wiley   +1 more source