Results 61 to 70 of about 78,581 (298)

Cholera toxin (CTX) genetic element in Vibrio cholerae O139 [PDF]

Microbiology, 1995
PFGE analysis of the Notl-and Sfil-digested genome of Vibrio cholerae O139 strains isolated from different epidemic regions of India showed that all the strains are of clonal origin and the genome size is about 2·2 Mb. An analysis of the electrophoretic profiles of the genome of O139 strains, the RFLP of the cholera toxin (ctx) gene and Southern blot ...
Rupak K, Bhadra, Susanta, Roychoudhury, Rajat K, Banerjee, Sujata, Kar, Ruma, Majumdar, Sanghamitra, Sengupta, Soma, Chatterjee, Gopal, Khetawat, Jyotirmoy, Das   +8 more
openaire   +2 more sources

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model

Nature Communications
The ongoing seventh cholera pandemic, which began in 1961, poses an escalating threat to public health. There is a need for new cholera control measures, particularly ones that can be produced at low cost, for the one billion people living in cholera ...
Marcus Petersson, Franz G. Zingl, Everardo Rodriguez-Rodriguez, Jakob K. H. Rendsvig, Heidi Heinsøe, Emma Wenzel Arendrup, Natalia Mojica, Dario Segura Peña, Nikolina Sekulić, Ute Krengel, Monica L. Fernández-Quintero, Timothy P. Jenkins, Lone Gram, Matthew K. Waldor, Andreas H. Laustsen, Sandra Wingaard Thrane   +15 more
doaj   +1 more source

Two Different Diagnosis Methods For The detection of cholera toxin production From Vibrio cholerae isolated from different areas in Iraq

The Iraqi Journal of Veterinary Medicine, 2010
Fifty isolates of Vibrio cholerae obtained from different areas in Iraq from patients with acute secretory diarrhea were diagnosed serologically in central public health laboratory(CPHL), Two different methods were used for detection cholera toxin ...
Atheer Abdulrazzaq
doaj   +1 more source

Grape extracts inhibit multiple events in the cell biology of cholera intoxication. [PDF]

PLoS ONE, 2013
Vibrio cholerae produces cholera toxin (CT), an AB5 protein toxin that is primarily responsible for the profuse watery diarrhea of cholera. CT is secreted into the extracellular milieu, but the toxin attacks its Gsα target within the cytosol of a host ...
Srikar Reddy, Michael Taylor, Mojun Zhao, Patrick Cherubin, Sandra Geden, Supriyo Ray, David Francis, Ken Teter   +7 more
doaj   +1 more source

Understanding the Anti-Diarrhoeal Properties of Incomptines A and B: Antibacterial Activity against Vibrio cholerae and Its Enterotoxin Inhibition

Pharmaceuticals, 2022
Incomptines A (IA) and B (IB) are two sesquiterpene lactones with antiprotozoal, antibacterial, cytotoxic, antitumor, spermicidal, and phytotoxic properties.
Fernando Calzada, Elihu Bautista, Sergio Hidalgo-Figueroa, Normand García-Hernández, Claudia Velázquez, Elizabeth Barbosa, Miguel Valdes, Jesús Iván Solares-Pascasio   +7 more
doaj   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Cholera toxin: Vibrio cholera's dehydration machine

The FASEB Journal, 2012
The Blue Valley Center for Advanced Professional Studies (BVCAPS) SMART Team members researched the actions of the microbe Vibrio cholera in causing the water born disease cholera, which infects millions of humans annually and causes death to thousands of individuals through extreme fluid ...
C. Anderson, D. Assyia, K. Bannerman, A. Fehr, J. Hermanson, N. Hron, J. Hsu, N. Larson, G. Long, J. Long, D. Mann, R. McLean, V. Menon, G. Mohar, F. Moret, V. Nguyen, K. O'Leary, K. Pedersen, R. Pohl, H. Reynolds, A. Rice, T. Rodriguez, A. Rottinghaus, T. Schaefer, T. Scott, K. Strombom, J. Vollick, G. Wehemyer, B. Whitcomb, A. Taghizadeh, J. Whalen, E. Kessler   +31 more
openaire   +1 more source

Structural inferences for Cholera toxin mutations in Vibrio cholerae [PDF]

Bioinformation, 2011
Cholera is a global disease that has persisted for millennia. The cholera toxin (CT) from Vibrio cholerae is responsible for the clinical symptoms of cholera. This toxin is a hetero-hexamer (AB(5)) complex consisting of a subunit A (CTA) with a pentamer (B(5)) of subunit B (CTB).
Gunasagaran, Shamini, Manickam, Ravichandran, John T, Sinnott, Charurut, Somboonwit, Harcharan S, Sidhu, Paul, Shapshak, Pandjassarame, Kangueane   +6 more
openaire   +2 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source