Results 121 to 130 of about 28,186 (243)

Hereditäre Defekte hepatobiliärer Transportproteine [PDF]

, 2018
Zusammenfassung: Eine gestörte Funktion hepatobiliärer Transportproteine kann zu schweren hereditären cholestatischen Leberkrankheiten führen. Die progressive familiäre intrahepatische Cholestase (PFIC) manifestiert sich im frühen Kindesalter.
Kullak-Ublick, G.A., Mwinyi, J.
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Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

The bile salt export pump [PDF]

, 2018
Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow.
Meier, Peter, Meier, Yvonne, Stieger, Bruno   +2 more
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The Risk Factors for Placental Abruption in Preeclamptic Pregnancies: A Retrospective Case–Control Study

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 5, May 2026.
ABSTRACT Aim Preeclampsia poses a high‐risk factor for placental abruption. The precise understanding of the accompanying symptoms and disease phenotype of preeclampsia, in order to promptly identify the occurrence of placental abruption in preeclamptic women, remains unclear.
Kechen Li, Qiaoqiao Lin, Anjian Xu, Jieni Zou, Li Zhou, Ying Hua, Qianmeng Huang   +6 more
wiley   +1 more source

Are Postprandial Bile Acid Levels Helpful in Predicting Perinatal Complications in Patients with Intrahepatic Cholestasis of Pregnancy?

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2015
Purpose: To determine the outcomes of Iintrahepatic cholestasis of pregnancy and the role of postprandial serum bile acid levels in the prediction of perinatal complications.
Kudret Erkenekli, Can Tekin iskender, Hasan Onur Topcu, Tugba Ensari, Dilek Uygur, Nuri Danisman   +5 more
doaj  

Baseline Alkaline Phosphatase Impacts Response Rates in Primary Biliary Cholangitis: Exploring Response to Elafibranor in ELATIVE

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background & Aims Baseline alkaline phosphatase (ALP) levels can influence the likelihood of achieving dichotomous biochemical response criteria in primary biliary cholangitis (PBC). This concept was explored using Week 52 data from the phase III ELATIVE trial (NCT04526665), which assessed elafibranor, a peroxisome proliferator‐activated ...
Cynthia Levy, Christopher L. Bowlus, Eric Lawitz, Nuno Antunes, Benjamin Miller, Jianfen Shu, Claudia O. Zein, Kris V. Kowdley   +7 more
wiley   +1 more source

Intrahepatic cholestasis of pregnancy

Canadian Medical Association Journal, 2022
Hobson, Sebastian, Gandhi, Shital, Sobel, Mara   +2 more
openaire   +2 more sources

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70‐Deficient Mice With a Human‐Like Bile Acid Composition

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Loss‐of‐function mutations in bile acid (BA)‐activated farnesoid x receptor (FXR/NR1H4) cause severe neonatal liver pathology in humans, earlier referred to as progressive familial intrahepatic cholestasis type 5 (PFIC5). However, Fxr‐deficient mice do not develop early‐onset liver disease, possibly due to the predominance ...
Hilde D. de Vries, Jinxiao Li, Kirill Ustyantsev, Milaine V. Hovingh, Niels L. Mulder, Rick Havinga, Anna Palmiotti, Krisztina de Bruyn, Brecht Attema, Ellen Weersing, Rachel E. Thomas, Vincent W. Bloks, Eugene Berezikov, Martijn van Faassen, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers   +16 more
wiley   +1 more source

Dermatoses Específicas da Gravidez [PDF]

, 2013
During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specific dermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the ...
Coutinho, I, Gameiro, R, Gonçalo, Margarida, Teixieira, V, Vieira, R   +4 more
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Idiopathic adulthood ductopenia: long-term follow-up after liver transplantation [PDF]

, 2001
In 1988, Ludwig et al proposed the term idiopathic adulthood ductopenia (IAD) for the condition of chronic cholestatic liver disease associated with loss of intrahepatic bile ducts of unknown etiology with clinical onset in adulthood (1).
Herraiz-Bayod, M.J. (Maite J.), Herrero, J.I. (José Ignacio), Pardo, F. (Fernando), Prieto, J. (Jesús), Quiroga, J. (Jorge), Rios, R. (Raquel), Sangro, B. (Bruno), Sola, J. (Josu), Álvarez-Cienfuegos, J. (Javier)   +8 more
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