Results 51 to 60 of about 139,121 (234)

Intrahepatic Cholestasis of Pregnancy: Natural History and Current Management

Seminars in liver disease (Print), 2021
Intrahepatic cholestasis of pregnancy (ICP) is a common disorder in the second half of pregnancy characterized by pruritus and elevated serum bile acids (BAs) with spontaneous resolution after delivery.
Rebecca Roediger, J. Fleckenstein
semanticscholar   +1 more source

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]

, 2012
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Müllenbach, Roman, Marcin Krawczyk, Weber, Susanne N., Grünhage, Frank, Sarrazin, Christoph, Zimmer, Vincent, Frank Grünhage, Krawczyk, Marcin, Lammert, Frank, Christoph Sarrazin, Roman Müllenbach, Susanne N Weber, Vincent Zimmer, Frank Lammert   +13 more
core   +2 more sources

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Canadian Journal of Gastroenterology and Hepatology, 2018
Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. Hereditary cholestasis is a heterogeneous group of rare autosomal recessive liver disorders, which are characterised by intrahepatic cholestasis ...
Eva Sticova, Milan Jirsa, Joanna Pawłowska   +2 more
doaj   +1 more source

Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?

Gynecology Obstetrics & Reproductive Medicine, 2021
OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis.
Hasan Eroglu, Harun Egemen Tolunay, Kemal Sarsmaz, Gokcen Orgul, Dilek Sahin, Aykan Yucel   +5 more
doaj   +1 more source

Genotypes and different clinical variants between children and adults in progressive familial intrahepatic cholestasis: a state-of-the-art review

Orphanet Journal of Rare Diseases
Progressive Familial intrahepatic cholestasis (PFIC) are rare disorders of bile acid (BAs) secretion and transport with a genetic background. PFIC are paediatric manifestations, but the same variants causing PFIC can also cause cholestasis with a later ...
Giovanni Vitale, M. Sciveres, Claudia Mandato, A. P. d'Adamo, A. Di Giorgio   +4 more
semanticscholar   +1 more source

A Link between Intrahepatic Cholestasis and Genetic Variations in Intracellular Trafficking Regulators

Biology, 2021
Simple Summary Cholestasis refers to a medical condition in which the liver is not capable of secreting bile. The consequent accumulation of toxic bile components in the liver leads to liver failure.
Qinghong Li, Yue Sun, S. V. van IJzendoorn   +2 more
semanticscholar   +1 more source

The prevalence and pregnancy outcomes of intrahepatic cholestasis of pregnancy: a retrospective clinical audit review

, 2018
Background To determine the prevalence and outcomes of intrahepatic cholestasis of pregnancy. Methods A review comparing intrahepatic cholestasis of pregnancy pregnancies to all other pregnancies in three tertiary care Australian hospitals over a 36 ...
Morton, Adam, McCuaig, Ruth, Arthur, Chris, Carins, Thomas, Gardiner, Fergus W, Laurie, Josephine, Peek, Michael J., Peek, Michael J, Gardiner, Fergus W., Lim, Boon, Neeman, Teresa   +10 more
core   +1 more source

Case Report: A Rare Heterozygous ATP8B1 Mutation in a BRIC1 Patient: Haploinsufficiency?

Frontiers in Medicine, 2022
Benign recurrent intrahepatic cholestasis (BRIC) is an autosomal recessive disorder characterized by recurrent cholestasis. ATPase class I, type 8B, member 1 (ATP8B1) encodes familial intrahepatic cholestasis 1 (FIC1), which acts as a phosphatidylserine ...
Hao Bing, Hao Bing, Yi-Ling Li, Dan Li, Chen Zhang, Bing Chang   +5 more
doaj   +1 more source

Progressive familial intrahepatic cholestasis

Definitions, 2020
Neonatal cholestasis is one of the commonest presentations in the field of pediatric hepatol‐ ogy and gastroenterology and constitutes the major indication for liver transplantation be‐ low two years of age. Unfortunately, in spite of being common, fewer
R. Khanna, Vipul Gautam
semanticscholar   +1 more source

Assessment of aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index score on women with intrahepatic cholestasis of pregnancyAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: Intrahepatic cholestasis of pregnancy is a pregnancy-related liver condition that is characterized by elevated liver function tests and/or bile acids in the presence of pruritis.
Maria Cemortan, PhD, Corina Iliadi-Tulbure, PhD, Irina Sagaidac, PhD, Olga Cernetchi, PhD   +3 more
doaj   +1 more source