Results 11 to 20 of about 960,807 (326)
Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwayss⃞ [PDF]
Journal of Lipid Research, 2007 Endocytosis of LDL and modified LDL represents regulated and unregulated cholesterol delivery to macrophages. To elucidate the mechanisms of cellular cholesterol transport and egress under both conditions, various primary macrophages were labeled and ...
Ming-Dong Wang +5 more
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Targeting LDL Cholesterol With LNA
Molecular Therapy: Nucleic Acids, 2012 Cardiovascular disease is the number one cause of death in the industrialized world. Much of the morbidity and mortality from heart disease can be linked to elevated low-density lipoprotein (LDL) cholesterol, and one of the key genes that increases LDL cholesterol is Proprotein convertase subtilisin/kexin type 9 (PCSK9).
Arthur M Krieg
doaj +3 more sources
When LDL Cholesterol Is Not LDL Cholesterol
JACC: Case Reports, 2022 LpX is a lipoprotein formed in cholestatic conditions and often erroneously reported as LDL-C. A low ApoB level can support the diagnosis of LpX. Treatment should not automatically focus on lowering serum lipid levels, but primarily on resolving the cause of cholestasis. (Level of Difficulty: Advanced.).
Lisa P.M. Huygen +3 more
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Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease [PDF]
Indian Journal of Clinical Biochemistry, 2006 Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and
Joya Ghosh +3 more
semanticscholar +3 more sources
LDL-Cholesterol-Lowering Therapy [PDF]
, 2020 AbstractThe causal relation between elevated levels of LDL-C and cardiovascular disease has been largely established by experimental and clinical studies. Thus, the reduction of LDL-C levels is a major target for the prevention of cardiovascular disease.
Giuseppe Danilo Norata +2 more
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Lowering LDL Cholesterol [PDF]
Circulation, 1999 Abstract —The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease (CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival Study (4S) and the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated that lipid lowering with a statin can ...
Antonio M. Gotto, Scott M. Grundy
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Journal of Lipid Research, 1990 The effects of dietary cholesterol and fatty acids on the plasma cholesterol level and rates of very low density lipoprotein (VLDL) cholesterol secretion and low density lipoprotein (LDL) transport through LDL receptors in the liver of the hamster were ...
H Ohtani +8 more
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Existing and emerging therapies for the treatment of familial hypercholesterolemia
Journal of Lipid Research, 2021 Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL-cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease.
Robert S. Rosenson
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Pathophysiology of elevated ascites fluid cholesterol in malignant ascites [PDF]
, 1992 The existence of marked elevations of ascitic fluid cholesterol has been observed in patients with peritoneal carcinomatosis compared to patients with cirrhosis and has been found useful in differential diagnosis.
Alexander L. Gerbes +27 more
core +1 more source