Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source
Lowering LDL Cholesterol [PDF]
Circulation, 1999 Abstract —The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease (CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival Study (4S) and the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated that lipid lowering with a statin can ...
Antonio M. Gotto, Scott M. Grundy
openaire +1 more source
Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects [PDF]
, 1986 The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood.
Brewer, HB +6 more
core +1 more source
Journal of Lipid Research, 1992 The aim of the present study was, first, to investigate whether cholesterol (C) absorption, enhanced by cholesterol feeding, was related to synthesis of cholesterol, serum level of low density lipoprotein (LDL)-C, and receptor activity for LDL ...
H Gylling, TA Miettinen
doaj +1 more source
Existing and emerging therapies for the treatment of familial hypercholesterolemia
Journal of Lipid Research, 2021 Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL-cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease.
Robert S. Rosenson
doaj +1 more source
Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]
, 2006 Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL +6 more
core +1 more source
Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2019 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Failing, Klaus +8 more
core +2 more sources
Journal of Lipid Research, 1990 The effects of dietary cholesterol and fatty acids on the plasma cholesterol level and rates of very low density lipoprotein (VLDL) cholesterol secretion and low density lipoprotein (LDL) transport through LDL receptors in the liver of the hamster were ...
H Ohtani +8 more
doaj +1 more source
Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome [PDF]
, 1987 The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis.
Appel +22 more
core +1 more source
Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results. [PDF]
, 2018 Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements.
Canaud, Bernard +11 more
core +3 more sources