Results 101 to 110 of about 25,663 (167)

25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway

Frontiers in Immunology
IntroductionTriple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic options. Reprogramming the tumor immune microenvironment (TIME) has emerged as a promising strategy for breast cancer treatment, and tumor-associated
Hongmei Zheng, Wenqin Huang, Panshi Zhang, Sudhanshu Bhushan, Xinhong Wu, Yalong Yang   +5 more
doaj   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus

Medicine Advances, Volume 4, Issue 2, Page 115-124, June 2026.
Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu, Yuan Tian, Hongbin Zhu, Bing Peng, Chunheng Mo   +4 more
wiley   +1 more source

An Unexpected Enzyme in Vascular Smooth Muscle Cells: Angiotensin II Upregulates Cholesterol-25-Hydroxylase Gene Expression. [PDF]

Int J Mol Sci, 2023
Kovács KB, Szalai L, Szabó P, Gém JB, Barsi S, Szalai B, Perey-Simon B, Turu G, Tóth AD, Várnai P, Hunyady L, Balla A.   +11 more
europepmc   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Nerve Ultrasound Detects Peripheral Nerve Enlargement in Cerebrotendinous Xanthomatosis

Muscle &Nerve, Volume 73, Issue 6, Page 1082-1088, June 2026.
ABSTRACT Introduction/Aims Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder caused by variants in the CYP27A1 gene, resulting in cholestanol accumulation in various tissues, including peripheral nerves. Polyneuropathy is common but often under‐recognized in CTX.
Antonio Edvan Camelo‐Filho, Pedro Lucas G. S. B. Lima, Tito B. S. Soares, Rodrigo Fagundes da Rosa, Luis Edmundo T. A. Furtado, Ana Lucila Moreira, André L. S. Pessoa, Paulo R. Nóbrega, Pedro Braga‐Neto   +8 more
wiley   +1 more source

Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling

Cellular and Molecular Life Sciences
Background and aims Oxysterols, oxidized derivatives of cholesterol, play complex roles in inflammatory processes, but their specific functions in inflammatory bowel diseases remain incompletely understood.
Hafsa Ameraoui, Joan Bestard-Escalas, Martin Roumain, Adam Laghouati, Pauline Bottemanne, Mireille Alhouayek, Giulio G. Muccioli   +6 more
doaj   +1 more source

Exploring the Effects of Metabolites from Lactobacillus rhamnosus GM020 and Cyanidin-3-O-Glucoside on Differential Metabolites in the High-fat Diet Mice Liver Based on Metabolomics

Shipin gongye ke-ji
Objective: Investigating the regulatory effects of cyanidin-3-O-glucoside (C3G) and Lactobacillus rhamnosus GM020 metabolite (C3G-GM020) on cholesterol metabolism in high-fat diet-fed mice using untargeted metabolomics.
Sihang WANG, Bin LI, Hui TAN, Xianjun MENG, Yongping XU, Shuying LI, Xiaoru LIU, Yuehua WANG, Yan MA   +8 more
doaj   +1 more source

Cholesterol 25-Hydroxylase [PDF]

, 2020
openaire   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 170-188, June 2026.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source