Intra‐tumoral oxygen deprivation (hypoxia) promotes the activation of hypoxia‐inducible factors (HIFs) that orchestrate the transcriptional adaptation of cancer cells to hypoxia. Hypoxia is prevalent in hepatocellular carcinoma (HCC), a cancer type with limited therapeutic options.
Ioanna‐Maria Gkotinakou +6 more
wiley +1 more source
Plant Peptides on the Rise: From Historical Insight to Future Applications
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang +5 more
wiley +1 more source
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure. [PDF]
Li H +6 more
europepmc +1 more source
Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway. [PDF]
Pokharel SM +4 more
europepmc +1 more source
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function. [PDF]
Sheng N +5 more
europepmc +1 more source
Cholesterol 25-Hydroxylase Enhances Myeloid-Derived Suppressor Cell (MDSC) Immunosuppression via the Stimulator of Interferon Genes (STING)-Tank-Binding Kinase 1 (TBK1)-Receptor-Interacting Protein Kinase 3 (RIPK3) Pathway in Colorectal Cancer. [PDF]
Zhou D +14 more
europepmc +1 more source
013 Cholesterol 25-hydroxylase expressing CD4+ T cell regulates skin inflammation [PDF]
H. Takahashi +8 more
openaire +1 more source
Porcine Reproductive and Respiratory Syndrome Virus E Protein Degrades Porcine Cholesterol 25-Hydroxylase via the Ubiquitin-Proteasome Pathway. [PDF]
Ke W +6 more
europepmc +1 more source

