Results 11 to 20 of about 6,635 (224)

Infant Formula Feeding Increases Hepatic Cholesterol 7α Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets. [PDF]

J Nutr, 2018
Mercer KE, Bhattacharyya S, Diaz-Rubio ME, Piccolo BD, Pack LM, Sharma N, Chaudhury M, Cleves MA, Chintapalli SV, Shankar K, Ronis MJJ, Yeruva L.   +11 more
europepmc   +3 more sources

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. [PDF]

J Lipid Res, 2016
Ferrell JM, Boehme S, Li F, Chiang JY.
europepmc   +3 more sources

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism [PDF]

, 2020
Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Angelini, Roberto, Baumert, Mark, Clench, Malcolm, Griffiths, William J., Howell, Owain W., Mast, Natalia, Newton, Jillian, Pikuleva, Irina, Skibinski, David O.F., Wang, Yuqin, Yutuc, Eylan   +10 more
core   +2 more sources

Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis. [PDF]

Cardiovasc Res, 2016
Krishnamurthy K, Glaser S, Alpini GD, Cardounel AJ, Liu Z, Ilangovan G.   +5 more
europepmc   +3 more sources

In nonhepatic cells, cholesterol 7α-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis

Journal of Lipid Research, 2000
CHO cells expressing the liver-specific gene product cholesterol-7α-hydroxylase showed a 6-fold increase in the biosynthesis of [14C]cholesterol from [14C]acetate, as well as increased enzymatic activities of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)
Gary M. Spitsen, Svein Dueland, Skaidrite K. Krisans, Casey J. Slattery, Jon H. Miyake, Roger A. Davis   +5 more
doaj   +1 more source

Current trends in oxysterol research [PDF]

, 2016
In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius, Alwena H. Morgan, Andersson, Arnoldi, Bauman, Blanc, Clayton, Crick, de Medina, Diczfalusy, Dietschy, Eylan Yutuc, Fakheri, Gill, Goyal, Hannedouche, Heverin, Horton, Hu, Iuliano, Iuliano, Janowski, Jansen, Javitt, Jonas Abdel-Khalik, Klinke, Leonarduzzi, Liu, Lütjohann, Maarup, Meaney, Meljon, Murphy, Nelson, Ogundare, Porter, Radhakrishnan, Reboldi, Russell, Sacchetti, Santori, Schroepfer, Shackleton, Song, Soroosh, Theofilopoulos, Theofilopoulos, Thomas Hearn, Tint, Umetani, Wang, Wang, William J. Griffiths, Wu, Yuqin Wang   +54 more
core   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. [PDF]

, 2015
BackgroundAmyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer's disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest.
Akula, Rajender, Ba, Saritha, Ceballos-Diaz, Carolina, Felsenstein, Kevin M, Golde, Todd E, Hochhaus, Günther, Jung, Joo In, Koo, Edward H, Ladd, Thomas B, Park, Hyo-Jin, Price, Ashleigh R, Ran, Yong, Shapiro, Gideon, Smithson, Lisa A, Tang, Yufei   +14 more
core   +3 more sources

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver

Journal of Lipid Research, 1999
The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3β-hydroxysterol Δ7-reductase, the final enzyme in the cholesterol biosynthetic pathway.
Akira Honda, Gerald Salen, Sarah Shefer, Ashok K. Batta, Megumi Honda, Guorong Xu, G. Stephen Tint, Yasushi Matsuzaki, Junichi Shoda, Naomi Tanaka   +9 more
doaj   +1 more source

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS ...
A Reboldi, A Saeed, A Solomon, A Szanto, AH Beecham, Andreas W. Sailer, B Goodwin, BA Janowski, C Hong, C Liu, CY Lee, D Meffre, DJ Parks, DR Bauman, DW Russell, F Chalmin, H Lassmann, I Björkhem, I Björkhem, I Björkhem, J Brown III, J Zhang, Jens Kuhle, JG Cyster, JG McDonald, JM Lehmann, Jonas Abdel-Khalik, Juan Zhang, K Park, L Mateos, LH Kasper, M Blanc, M Inoue, M Ogundare, MA Friese, Martin Beibel, N Zelcer, NJ Spann, P Soroosh, Peter J. Crick, PJ Crick, S Hannedouche, S Meaney, S Theofilopoulos, SV Ramagopalan, SY Liu, U Diczfalusy, V Leoni, William J. Griffiths, Y Wang, Yuqin Wang, Z Wang   +51 more
core   +1 more source