Results 21 to 30 of about 316,404 (122)
Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1
Journal of Lipid Research, 2004 Cytochrome P450 27A1 (P450 27A1) is an important metabolic enzyme involved in bile acid biosynthesis and the activation of vitamin D3 in mammals.
Dilyara A. Murtazina +5 more
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Stimulation of cholesterol 7α-hydroxylase by phenobarbital in two strains of rats
Journal of Lipid Research, 1972 The effect of phenobarbital administration on the in vitro activity of cholesterol 7α-hydroxylase was investigated in two strains of rats. In rats of the Wistar strain the daily injection of phenobarbital (100 mg/kg per day ip for 5 days) produced a 33 ...
S. Shefer, S. Hauser, E.H. Mosbach
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Gene expression of hepatic cholesterol 7α-hydroxylase in the course of puromycin-induced nephrosis [PDF]
, 1996 Gene expression of hepatic cholesterol 7α-hydroxylase in the course of puromycin-induced nephrosis. Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals.
Liang, Kai Hui +2 more
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Structural characterization of human cholesterol 7α-hydroxylase
Journal of Lipid Research, 2014 Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol.
Wolfram Tempel +7 more
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Journal of Lipid Research, 1976 Cholesterol 7α-hydroxylase activity was assayed in liver microsomes from guinea pigs supplemented with ascorbate and from guinea pigs in a state of ascorbate deficiency.
I Björkhem, A Kallner
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iScience, 2020 Summary: Neuroactive steroids, termed neurosteroids, are synthesized locally in the brain and influence biological functions including cognition and behavior.
Kanako Maehata +8 more
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On the heterogeneity of the mitochondrial C27-steroid 26-hydroxylase system
Journal of Lipid Research, 1976 Mitochondrial 26-hydroxylation of exogenous cholesterol, endogenous cholesterol, and 5β-cholestane-3α,7α,12α-triol was studied. 26-Hydroxylation of endogenous cholesterol was measured by mass fragmentography.
J Gustafsson
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HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia [PDF]
, 2003 HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia.BackgroundHereditary analbuminemia is associated with hypercholesterolemia, which has been shown to be primarily caused by increased ...
Liang, Kaihui, Vaziri, Nosratola D.
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The use of [7α-3H]- and [7α, 7β-3H]cholesterol in the enzymic assay of cholesterol 7α-hydroxylase
Journal of Lipid Research, 1976 A tritium release method is described for following the enzymic conversion of cholesterol to 7α-hydroxycholesterol. Incubations of rat liver subcellular preparations (containing microsomes) with [7α-3H]cholesterol or [7α,7β-3H]cholesterol release the ...
D B Johnson, M P Tyor, L Lack
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Determination of hepatic cholesterol 7α-hydroxylase activity in man
Journal of Lipid Research, 1974 Methods were developed to determine the activity of the microsomal enzyme cholesterol 7α-hydroxylase in human liver. The enzyme assay could be performed with as little as 20 mg of fresh liver tissue, thus making the procedure applicable to specimens ...
G. Nicolau +3 more
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