Results 21 to 30 of about 5,987 (179)

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver

Journal of Lipid Research, 1999
The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3β-hydroxysterol Δ7-reductase, the final enzyme in the cholesterol biosynthetic pathway.
Akira Honda, Gerald Salen, Sarah Shefer, Ashok K. Batta, Megumi Honda, Guorong Xu, G. Stephen Tint, Yasushi Matsuzaki, Junichi Shoda, Naomi Tanaka   +9 more
doaj   +1 more source

Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus [PDF]

, 1995
We investigated the lobular localization and molecular level of expression of cholesterol 7α-hydroxylase and sterol 27-hydroxylase, two key enzymes in bile acid synthesis, in isolated periportal and pericentral hepatocytes and by in situ hybridization of
Moorman, A.F.M., Twisk, J.W.R., M F Hoekman, Gebhardt, R., A F Moorman, H M Princen, Sheja, L., Twisk, J., W H Mager, J Twisk, Scheja, L., Moorman, A. F., Boer, P.A.J. de, L Scheja, de Boer, P. A., Princen, H. M., R Gebhardt, Mager, W. H., Mager, W.H., Hoekman, M. F., Princen, H.M.G., de Boer, P.A.J., Hoekman, M.F.M., P A de Boer, Gebhart, R.   +24 more
core   +1 more source

Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion

Journal of Lipid Research, 1998
The effect of cholesterol feeding (3 g/day) on bile acid synthesis was examined in 10 New Zealand white rabbits (NZW), 8 Watanabe heterozygous and 10 homozygous rabbits with partial and complete deficiencies of LDL receptors. After 10 days of cholesterol
Guorong Xu, Gerald Salen, Sarah Shefer, G. Stephen Tint, Lien B. Nguyen, Thomas T. Parker, Thomas S. Chen, Jeremy Roberts, Xianglin Kong, David Greenblatt   +9 more
doaj   +1 more source

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research, 2000
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu, Benjamin L. Shneider, Sarah Shefer, Lien B. Nguyen, Ashok K. Batta, G. Stephen Tint, Marco Arrese, Sundararajah Thevananther, Lin Ma, Siegfried Stengelin, Werner Kramer, David Greenblatt, Mark Pcolinsky, Gerald Salen   +13 more
doaj   +1 more source

Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1

Journal of Lipid Research, 1999
Oxysterol 7α-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism.
Zhengliang Wu, K.O. Martin, N.B. Javitt, J.Y.L. Chiang   +3 more
doaj   +1 more source

Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription

Journal of Lipid Research, 2000
Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor α (PPARα).
Maria Marrapodi, John Y.L. Chiang
doaj   +1 more source

Studies on the formation of C7-oxygenated cholesterol and β-sitosterol metabolites in cell-free preparations of rat liver

Journal of Lipid Research, 1973
The microsomal fraction and the 18,000 g supernatant fluid obtained from livers from normal rats, cholestyraminetreated rats, or from rats with a bile fistula have been used to compare the 7α-hydroxylation of [4-14C]cholesterol and β-[4-14C]sitosterol ...
Leif Aringer, Peter Eneroth
doaj   +1 more source

Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7α-hydroxylase activities

Journal of Lipid Research, 1977
Short- and long-term effects of ethanol on HMG-CoA reductase (EC 1.1.1.34) and cholesterol 7α-hydroxylase activities in rat liver have been investigated.
M R Lakshmanan, R L Veech
doaj   +1 more source

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K., Parhofer, K. G., Fischer, S., Sauter, G. H., Jungst, D., Jungst, C.   +5 more
core   +1 more source

Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7α-hydroxylase in rabbits fed cholesterol

Journal of Lipid Research, 2001
To study the effect of cholecystectomy on the regulation of classic and alternative bile acid syntheses, gallbladder-intact (n = 20) and cholecystectomized (n = 20) New Zealand White rabbits were fed either chow or chow with 2% cholesterol (3 g/day ...
Guorong Xu, Gerald Salen, Benjamin L. Shneider, M. Ananthanarayanan, Sarah Shefer, Lin Ma, Ashok Batta, Lien B. Nguyen, Josephine J. Lingutla, G. Stephen Tint, Mark Pcolinsky, Frederick J. Suchy   +11 more
doaj   +1 more source