Results 1 to 10 of about 39,047 (152)

VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice [PDF]

Microbiology Spectrum
Pathogen infections remain a significant public health problem worldwide. Accumulating evidence regarding the crosstalk between bile acid (BA) metabolism and immune response reveals that BA metabolism regulates host immunity and microbial pathogenesis ...
Yamei Li, Yan Luo, Chao Wang, Lei Xu, Xinhua Dai, Yunfei An, Lin He, Dongmei Zeng, Yangjuan Bai, Hua Zhang   +9 more
doaj   +6 more sources

Gut Bifidobacterium pseudocatenulatum protects against fat deposition by enhancing secondary bile acid biosynthesis [PDF]

iMeta
Gut microbiome is crucial for lipid metabolism in humans and animals. However, how specific gut microbiota and their associated metabolites impact fat deposition remains unclear.
Andong Zha, Ming Qi, Yuankun Deng, Hao Li, Nan Wang, Chengming Wang, Simeng Liao, Dan Wan, Xia Xiong, Peng Liao, Jing Wang, Yulong Yin, Bi'e Tan   +12 more
doaj   +3 more sources

Biosynthesis and biotransformation of bile acids [PDF]

Hospital Pharmacology, 2017
Bile acids are steroidal compounds, which contain 24 carbon atoms. They can be classified into two major groups: primary and secondary. The most abundant bile acids: The primary bile acids include cholic acid and chenodeoxycholic acid, while the major ...
Šarenac Tanja M., Mikov Momir M.
doaj   +3 more sources

Peroxisomes and bile acid biosynthesis

Biochimica Et Biophysica Acta - Molecular Cell Research, 2006
Peroxisomes play an important role in the biosynthesis of bile acids because a peroxisomal beta-oxidation step is required for the formation of the mature C24-bile acids from C27-bile acid intermediates. In addition, de novo synthesized bile acids are conjugated within the peroxisome. In this review, we describe the current state of knowledge about all
Sacha Ferdinandusse, Sander M Houten
exaly   +4 more sources

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis [PDF]

Clinical Gastroenterology and Hepatology, 2009
Primary (idiopathic) bile acid malabsorption (BAM) is a common, yet underrecognized, chronic diarrheal syndrome. Diagnosis is difficult without selenium homocholic acid taurine (SeHCAT) testing. The diarrhea results from excess colonic bile acids, but the pathogenesis is unclear. Fibroblast growth factor 19 (FGF19), produced in the ileum in response to
Julian R F Walters, Tracy Dew, Carel W Le Roux   +2 more
exaly   +3 more sources

Biochemical site of regulation of bile acid biosynthesis in the rat

Journal of Lipid Research, 1970
The production of bile salts by rat liver is regulated by a feedback mechanism, but it is not known which enzyme controls endogenous bile acid synthesis.
SARAH SHEFER, SUSAN HAUSER, IHOR BEKERSKY, ERWIN H. MOSBACH   +3 more
doaj   +3 more sources

Feedback regulation of bile acid biosynthesis in the rat

Journal of Lipid Research, 1969
The hepatic biosynthesis of bile salts in the rat has been shown to be controlled homeostatically by the quantity of bile salt returning to the liver via the portal circulation. The feedback mechanism was demonstrated in two kinds of experiments.
Shefer Sarah, Susan Hauser, Ihor Bekersky, Erwin H. Mosbach   +3 more
doaj   +3 more sources

Gut Microbiota-Mediated Elevated Production of Secondary Bile Acids in Chronic Unpredictable Mild Stress

Frontiers in Pharmacology, 2022
A growing body of evidence suggests that gut microbiota could participate in the progression of depression via the microbiota–gut–brain axis. However, the detailed microbial metabolic profile changes in the progression of depression is still not fully ...
Yuchen Qu, Cunjin Su, Qinhong Zhao, Aiming Shi, Fenglun Zhao, Liuxing Tang, Delai Xu, Zheng Xiang, Yang Wang, Yueyuan Wang, Jie Pan, Yunli Yu   +11 more
doaj   +1 more source

Integrated transcriptome and metabolome analysis reveals a possible mechanism for the regulation of lipid metabolism via vitamin A in rice field eel (Monopterus albus)

Frontiers in Physiology, 2023
To understand the effects of vitamin A on lipid deposition in rice field eels, integrated liver transcriptome and metabolome were conducted and the changes in the genes and metabolites were assessed.
Huanhuan Huo, Huanhuan Huo, Chonghua Hu, Qiubai Zhou, Qiubai Zhou, Liufeng Xiong, Liufeng Xiong, Mo Peng, Mo Peng   +8 more
doaj   +1 more source

Effects of Previous Kasai Surgery on Gut Microbiota and Bile Acid in Biliary Atresia With End-Stage Liver Disease

Frontiers in Medicine, 2021
Background and Aims: Biliary atresia (BA) is the most common cholestatic liver disease in neonates. Although the Kasai procedure can improve temporary biliary drainage in some cases, complications and liver fibrosis still develop.
Wei Song, Wei Song, Li-Ying Sun, Li-Ying Sun, Li-Ying Sun, Zhi-Jun Zhu, Zhi-Jun Zhu   +6 more
doaj   +1 more source