Results 31 to 40 of about 39,146 (248)

Identification of (24E)-3 alpha,7 alpha-dihydroxy-5 beta-cholest-24-enoic acid and (24R,25S)-3 alpha,7 alpha,24-trihydroxy-5 beta-cholestanoic acid as intermediates in the conversion of 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid to chenodeoxycholic acid in rat liver homogenates.

Journal of Lipid Research, 1994
Studies of chemical structure of the intermediates in the biosynthetic sequence between 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) and chenodeoxycholic acid have been undertaken. Radiolabeled DHCA was incubated with a rat liver preparation.
M. Une, A. Inoue, T. Kurosawa, M. Tohma, T. Hoshita   +4 more
doaj   +1 more source

Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling

Metabolites, 2020
Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism.
Junliang Kuang, Xiaojiao Zheng, Fengjie Huang, Shouli Wang, Mengci Li, Mingliang Zhao, Chao Sang, Kun Ge, Yitao Li, Jiufeng Li, Cynthia Rajani, Xiaohui Ma, Shuiping Zhou, Aihua Zhao, Wei Jia   +14 more
doaj   +1 more source

Bile Acid Biosynthesis Avoiding Cholesterol [PDF]

, 2018
Abstract Bile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine. Here we have investigated the bile acid content of plasma and urine from patients with a defect in cholesterol biosynthesis, i.e.
Griffiths, William J., Abdel-Khalik, Jonas, Crick, Peter J., Yutuc, Eylan, Ogundare, Michael, Bigger, Brian W., Morris, Andrew A., Shackleton, Cedric H., Clayton, Peter T., Iida, Takashi, Sircar, Ria, Marschall, Hanns-Ulrich, Sjövall, Jan, Björkhem, Ingemar, Rohatgi, Rajat, Wang, Yuqin   +15 more
openaire   +1 more source

PGC-1α Activates CYP7A1 and Bile Acid Biosynthesis [PDF]

Journal of Biological Chemistry, 2003
Cholesterol 7-alpha-hydroxylase (CYP7A1) is the key enzyme that commits cholesterol to the neutral bile acid biosynthesis pathway and is highly regulated. In the current studies, we have uncovered a role for the transcriptional co-activator PGC-1alpha in CYP7A1 gene transcription. PGC-1alpha plays a vital role in adaptive thermogenesis in brown adipose
Shin, Dong-Ju, Campos-Sandoval, José Ángel, Gil, Gregorio, Osborne, Timothy F.   +3 more
openaire   +4 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Preparation of 24(R)- and 24(S)-5β-cholestane-3α,7α,24-triols and 25(R)- and 25(S)-5β-cholestane-3α,7α,26-triols by a hydroboration procedure

Journal of Lipid Research, 1978
This report describes a new and convenient method for the preparation of 5β-cholestane-3α,7α,24-triol (24R and 24S) and 5β-cholestane-3α,7α,26-triol (25R and 25S) starting from 5β-cholestane-3α,7α,25-triol. Dehydration of the latter with acetic anhydride
B Dayal, A K Batta, S Shefer, G S Tint, G Salen, E H Mosbach   +5 more
doaj   +1 more source

Dietary bile acids supplementation mainly regulates the amino acid metabolic pathways without decreasing bile acids levels in the liver of farmed European eel (Anguilla anguilla) juveniles

Aquaculture Reports, 2022
This study was conducted to investigate the effects of dietary bile acids (BAs) supplementation on the liver metabolism of farmed European eel (Anguilla anguilla) juveniles.
Yiyao Yu, Panyue Zhao, Shaowei Zhai
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

The anticancer activity of bile acids in drug discovery and development

Frontiers in Pharmacology
Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system.
Weijian Li, Weijian Li, Weijian Li, Weijian Li, Lu Zou, Lu Zou, Lu Zou, Lu Zou, Shuai Huang, Huijie Miao, Huijie Miao, Huijie Miao, Huijie Miao, Ke Liu, Ke Liu, Ke Liu, Ke Liu, Yajun Geng, Yajun Geng, Yajun Geng, Yajun Geng, Yingbin Liu, Yingbin Liu, Yingbin Liu, Yingbin Liu, Wenguang Wu, Wenguang Wu, Wenguang Wu, Wenguang Wu   +28 more
doaj   +1 more source