Results 21 to 30 of about 2,795,829 (201)

Regulation of bile acid synthesis in the rat: relationship between hepatic cholesterol 7 alpha-hydroxylase activity and portal bile acids.

Journal of Lipid Research, 1995
Bile acid biosynthesis has been believed to be regulated by negative feedback control; however, recent experiments have cast considerable doubts on the concept. The aim of the study was to examine the consensus of the negative feedback regulation of bile
K Fukushima, H Ichimiya, H Higashijima, H Yamashita, S Kuroki, K Chijiiwa, M Tanaka   +6 more
doaj   +1 more source

Effect of biliary obstruction on 26-hydroxylation of C27-steroids in bile acid synthesis

Journal of Lipid Research, 1978
The effect of biliary obstruction on side chain hydroxylations in the biosynthesis and metabolism of bile acids was studied in the rat. For comparison, several other hydroxylation reactions in bile acid biosynthesis and metabolism were assayed.
J Gustafsson
doaj   +1 more source

Functional analysis of four bile salt hydrolase and penicillin acylase family members in Lactobacillus plantarum WCFS1 [PDF]

, 2008
Bile salts play an important role in the digestion of lipids in vertebrates and are synthesized and conjugated to either glycine or taurine in the liver.
Lambert, J.M., Vos, W.M., de, Kleerebezem, M., Bongers, R.S., de Vos, W.M.   +4 more
core   +1 more source

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source

New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]

, 2013
This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
core   +1 more source

Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat

Journal of Lipid Research, 1993
Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation.
MP Jones, WM Pandak, DM Heuman, JY Chiang, PB Hylemon, ZR Vlahcevic   +5 more
doaj   +1 more source

Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling

Journal of Pharmaceutical Analysis, 2023
It is necessary to explore potent therapeutic agents via regulating gut microbiota and metabolism to combat Parkinson's disease (PD). Dioscin, a bioactive steroidal saponin, shows various activities.
Zhang Mao, Haochen Hui, Xuerong Zhao, Lina Xu, Yan Qi, Lianhong Yin, Liping Qu, Lan Han, Jinyong Peng   +8 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects [PDF]

, 2008
A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology.
Bajor, Antal
core   +1 more source

Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease [PDF]

, 1993
There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients.
Niemeyer, A., Ritter, C., Lange, V., Pozo, R., Meyer, L., Jüngst, Dieter, Richter, Werner O., Brandl, H., Möhrle, W.   +8 more
core   +1 more source