Results 21 to 30 of about 39,146 (248)

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Dietary supplementation of porcine bile acids improves laying performance, serum lipid metabolism and cecal microbiota in late-phase laying hens

Animal Nutrition, 2022
Due to the exceptional laying performance of hens, the demand on lipid metabolism and oxidation in vivo is vigorous, resulting in excessive lipid accumulation in late-phase hens, which lowers the production performance.
Bowen Yang, Shimeng Huang, Guoxian Zhao, Qiugang Ma   +3 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver

Journal of Lipid Research, 2013
Here, we studied the effects of cytochrome P450 (CYP)3A deficiency on the mRNA expression of genes encoding regulators of hepatic cholesterol levels using Cyp3a-knockout (Cyp3a−/−) mice.
Mari Hashimoto, Kaoru Kobayashi, Mio Watanabe, Yasuhiro Kazuki, Shoko Takehara, Asumi Inaba, Shin-ichiro Nitta, Naoto Senda, Mitsuo Oshimura, Kan Chiba   +9 more
doaj   +1 more source

Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27−/− mice and CTX

Journal of Lipid Research, 2001
Cerebrotendinous xanthomatosis (CTX) is a rare, recessively inherited lipid storage disease characterized by a markedly reduced production of chenodeoxycholic acid and an increased formation of 25-hydroxylated bile alcohols and cholestanol. Patients with
Akira Honda, Gerald Salen, Yasushi Matsuzaki, Ashok K. Batta, Guorong Xu, Eran Leitersdorf, G. Stephen Tint, Sandra K. Erickson, Naomi Tanaka, Sarah Shefer   +9 more
doaj   +1 more source

Correlations of bile acids in the bile of rats in conditions of alloxan induced diabetes melitus [PDF]

The Ukrainian Biochemical Journal, 2014
The ratio of bile acids in the bile of rats with alloxan diabetes was investigated using the method of thin-layer chromatography. Changes of coefficients of conjugation and hydroxylation of bile acids were calculated and analyzed in half-hour samples of ...
N. N. Danchenko, S. P. Veselskiy, B. А. Tsydzevich   +2 more
doaj   +1 more source

Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.

Journal of Lipid Research, 1990
Under most experimental conditions, the activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase) and cholesterol 7 alpha-hydroxylase, change together in parallel directions.
WM Pandak, DM Heuman, PB Hylemon, ZR Vlahcevic   +3 more
doaj   +1 more source

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle

Animals, 2022
Myostatin (MSTN) is a major negative regulator of skeletal muscle mass and causes a variety of metabolic changes. However, the effect of MSTN knockout on bile acid metabolism has rarely been reported.
Di Wu, Mingjuan Gu, Zhuying Wei, Chunling Bai, Guanghua Su, Xuefei Liu, Yuefang Zhao, Lei Yang, Guangpeng Li   +8 more
doaj   +1 more source

Regulation of cholesterol-7α-hydroxylase: BAREly missing a SHP

Journal of Lipid Research, 2002
Cholesterol-7α-hydroxylase (CYP7A1) regulates the pathway through which cholesterol is converted into bile acids. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids
Roger A. Davis, Jon H. Miyake, To Yuen Hui, Nathanael J. Spann   +3 more
doaj   +1 more source

Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
ContextAs a novel SGLT1 inhibitor, SY-009 has been preliminarily confirmed in a phase Ib clinical study for its ability to reduce postprandial blood glucose in patients with type 2 diabetes mellitus (T2DM).
Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li   +12 more
doaj   +1 more source