Results 11 to 20 of about 5,987 (179)

Structural characterization of human cholesterol 7α-hydroxylase [PDF]

Journal of Lipid Research, 2014
Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol.
Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich   +7 more
doaj   +2 more sources

Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding

Journal of Lipid Research, 2001
Bile acids are synthesized via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1), and via alternate pathways, one of which is initiated by sterol 27-hydroxylase (CYP27).
Margrit Schwarz, David W Russell, John M Dietschy   +2 more
exaly   +3 more sources

Association of the A-204C polymorphism in the cholesterol 7α-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study

Journal of Lipid Research, 1999
The first reaction of the catabolic pathway of cholesterol is catalyzed by CYP7 and serves as the rate-limiting step and major site of regulation of bile acid synthesis in the liver.
Patrick Couture, James D Ötvös, L Adrienne Cupples   +2 more
exaly   +3 more sources

Marked reduction in bile acid synthesis in cholesterol 7α-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia

Journal of Lipid Research, 1998
These studies used mice that were deficient in cholesterol 7α-hydroxylase to determine the effects of reduced bile acid synthesis on cholesterol homeostasis.
Margrit Schwarz, David W Russell, John M Dietschy   +2 more
exaly   +3 more sources

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +2 more sources

Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene. [PDF]

Croat Med J, 2016
Aim To determine whether the promoter polymorphism -203A>C of cholesterol-7α-hydroxylase encoding gene (CYP7A1) affects diurnal variation in CYP7A1 enzyme activity.
Vlachova M, Blahova T, Lanska V, Leníček M, Pitha J, Vítek L, Kovar J.   +6 more
europepmc   +2 more sources

In nonhepatic cells, cholesterol 7α-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis

Journal of Lipid Research, 2000
CHO cells expressing the liver-specific gene product cholesterol-7α-hydroxylase showed a 6-fold increase in the biosynthesis of [14C]cholesterol from [14C]acetate, as well as increased enzymatic activities of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)
Gary M. Spitsen, Svein Dueland, Skaidrite K. Krisans, Casey J. Slattery, Jon H. Miyake, Roger A. Davis   +5 more
doaj   +1 more source

Expression of cholesterol 7α-hydroxylase and Δ4-3-ketosteroid 5β-reductase genes in rat pancreatic hepatocyte-like cells

Journal of Lipid Research, 1999
Hepatocyte-like cells have been observed in the pancreas of the rat. We examined the bile acid biosynthetic function of these cells to determine whether they were real hepatocytes.
Yoshihisa Ando, Hideyuki Ide, Shuji Kosai, Ryo Kamimura, Yorio Maeda, Shushi Higashi, Toshiaki Setoguchi   +6 more
doaj   +1 more source

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Regulatory effects of sterols and bile acids on hepatic 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol 7α-hydroxylase in the rat

Journal of Lipid Research, 1973
Specific activities of the hepatic microsomal enzymes 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase and cholesterol 7α-hydroxylase were studied in rats fed sterols and bile acids.
S. Shefer, S. Hauser, V. Lapar, E.H. Mosbach   +3 more
doaj   +1 more source