Results 91 to 100 of about 82,690 (331)

Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background The contribution of high‐density lipoprotein to cardiovascular benefit is closely linked to its role in the cellular cholesterol efflux process; however, various clinical and biochemical variables are known to modulate the overall cholesterol ...
Julie Gall, Eric Frisdal, Randa Bittar, Wilfried Le Goff, Eric Bruckert, Philippe Lesnik, Maryse Guerin, Philippe Giral   +7 more
doaj   +1 more source

In silico simulation of reversible and irreversible swelling of mitochondria: The role of membrane rigidity [PDF]

, 2020
Mitochondria have been widely accepted as the main source of ATP in the cell. The inner mitochondrial membrane (IMM) is important for the maintenance of ATP production and other functions of mitochondria.
Arieli, Baranov, Bazil, Bazil, Beavis, Bernardi, Bernardi, Bernardi, Brenner, Carraro, Carroll, Chapa-Dubocq, Crockett, Giorgi, Griffiths, Halestrap, Halestrap, Halestrap, Halestrap, Hollander, Holmuhamedov, Hoppe, Ichas, Ichas, Igor Khmelinskii, Javadov, Javadov, Javadov, Kirichok, Kuznetsov, Kwong, Ladbrooke, Lehninger, Lopez-Crisosto, Makarov, Massari, O'Rourke, Palmer, Petronilli, Pokhilko, Sabzali Javadov, Scalettar, Selivanov, Shinitzky, Song, Szabo, Vladimir I. Makarov, Wodtke, Zaza Khuchua   +48 more
core   +1 more source

Expression of Concern: Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors [PDF]

, 2023

openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells [PDF]

, 2018
Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation.
Bartholomew, Christopher, Biswas, Lincoln, Farhan, Fahad, Reilly, James, Shu, Xinhua   +4 more
core   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Exchange and mass efflux of cholesterol in macrophages. Evidence for a common mechanism and a role for plasma membrane proteins.

Journal of Lipid Research, 1987
Exchange and net mass efflux of cholesterol were investigated in [3H]cholesterol-labeled or cholesteryl ester-loaded murine peritoneal macrophages, respectively.
R K Randolph, H F Hoff
doaj   +1 more source

Familial hypercholesterolaemia: cholesterol efflux and coronary disease [PDF]

European Journal of Clinical Investigation, 2016
AbstractBackgroundCoronary heart disease (CHD) risk inversely associates with levels of high‐density lipoprotein cholesterol (HDL‐C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.Materials and methodsWe compared plasma cholesterol efflux capacity between male familial ...
Jorie Versmissen, Ranitha Vongpromek, Reyhana Yahya, Jeroen B. van der Net, Leonie van Vark‐van der Zee, Jeannette Blommesteijn‐Touw, Darcos Wattimena, Trinet Rietveld, Clive R. Pullinger, Christina Christoffersen, Björn Dahlbäck, John P. Kane, Monique Mulder, Eric J. G. Sijbrands   +13 more
openaire   +4 more sources

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, EarlyView.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity[S]

Journal of Lipid Research, 2015
Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair
Tomáš Vaisar, Chongren Tang, Ilona Babenko, Patrick Hutchins, Jake Wimberger, Anthony F. Suffredini, Jay W. Heinecke   +6 more
doaj   +1 more source