Results 261 to 270 of about 80,716 (308)

Associations Between High-Density Lipoprotein Cholesterol Efflux and Brain Grey Matter Volume. [PDF]

J Clin Med
Giacona JM, Wang J, Zhang R, Kelley BJ, Hajjar I, Thomas BP, Yu FF, de Lemos JA, Rohatgi A, Vongpatanasin W.   +9 more
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Transintestinal cholesterol efflux

Current Opinion in Lipidology, 2010
Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role of the intestine in cholesterol transport.In recent
Astrid E, van der Velde, Gemma, Brufau, Albert K, Groen   +2 more
openaire   +5 more sources

Cellular cholesterol efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2001
Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
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Genetics of Cholesterol Efflux

Current Atherosclerosis Reports, 2012
Plasma levels of high-density lipoprotein cholesterol (HDL-C) show an inverse association with coronary heart disease (CHD). As a biological trait, HDL-C is strongly genetically determined, with a heritability index ranging from 40 % to 60 %. HDL represents an appealing therapeutic target due to its beneficial pleiotropic effects in preventing CHD ...
Iulia, Iatan, Aurélien, Palmyre, Sarah, Alrasheed, Isabelle, Ruel, Jacques, Genest   +4 more
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Different Pathways of Cellular Cholesterol Efflux

Cell Biochemistry and Biophysics, 2022
Cholesterol efflux is the first and rate-limiting step of reverse cholesterol transport (RCT) from peripheric cells to the liver. The involvement of high-density lipoprotein (HDL) in RCT determines the atheroprotective properties of HDL. Cholesterol efflux from different membrane pools includes both passive and energy-dependent processes.
Alexander D, Dergunov, Veronika B, Baserova   +1 more
openaire   +2 more sources

Cholesterol Efflux and Reverse Cholesterol Transport: Experimental Approaches

Current Medicinal Chemistry, 2016
Cholesterol efflux as a key event in reverse cholesterol transport (RCT) is considered now as both diagnostic tool and a promising target for the treatment of atherosclerosis. Radioactive in vitro cholesterol efflux assay (CEA) is the gold standard for determination of efflux at cellular level. Fluorescent tracers and stable isotope-labeled cholesterol
Dmitry Y, Litvinov, Eugeny V, Savushkin, Evdokiya A, Garaeva, Alexander D, Dergunov   +3 more
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Quantifying Cellular Cholesterol Efflux

2019
Measuring cholesterol efflux involves the tracking of cholesterol movement out of cells. Cholesterol efflux is an essential mechanism to maintain cellular cholesterol homeostasis, and this process is largely regulated via the LXR transcription factors and their regulated genes, the ATP-binding cassette (ABC) cholesterol transporters ABCA1 and ABCG1 ...
Sabrina, Robichaud, Mireille, Ouimet
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New insights into cholesterol efflux via ABCA1

Nature Cardiovascular Research, 2022
ABCA1 promotes the efflux of cholesterol from cells to HDL and has anti-atherogenic activities. Sun and Li present cryo-EM structures of ABCA1 in the ATP-free and ATP-bound states, which reveal bound cholesterol molecules and suggest a transmembrane cholesterol-transport mechanism.
Alan R. Tall, Nan Wang
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Cholesterol Efflux: Mechanism and Regulation

1986
The removal of cholesterol from peripheral cells by HDL is the first step in what has become known as reverse cholesterol transport. This process involves the efflux of free cholesterol from the membrane of cells and the transport of the cholesterol to the liver1.
G H, Rothblat, M C, Phillips
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Regulation of cholesterol efflux from macrophages

Current Opinion in Lipidology, 2008
The lipid efflux pathway is important for both HDL formation and the reverse cholesterol transport pathway. This review is focused on recent findings on the mechanism of lipid efflux and its regulation, particularly in macrophages.Significant progress has been made on understanding the sequence of events that accompany the interaction of ...
Yves L, Marcel, Mireille, Ouimet, Ming-Dong, Wang   +2 more
openaire   +2 more sources