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Cholesterol Efflux: Mechanism and Regulation
1986The removal of cholesterol from peripheral cells by HDL is the first step in what has become known as reverse cholesterol transport. This process involves the efflux of free cholesterol from the membrane of cells and the transport of the cholesterol to the liver1.
G H, Rothblat, M C, Phillips
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Role of apolipoproteins in cellular cholesterol efflux
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986The effects of serum apolipoproteins, particle size and concentration on the effectiveness of phosphatidylcholine (PC)-containing acceptor particles in causing release of cholesterol from cells growing in culture have been investigated. The acceptor particles were prepared by detergent-dialysis procedures and were either egg PC small unilamellar ...
J, DeLamatre +3 more
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Quantifying Cellular Cholesterol Efflux
2019Measuring cholesterol efflux involves the tracking of cholesterol movement out of cells. Cholesterol efflux is an essential mechanism to maintain cellular cholesterol homeostasis, and this process is largely regulated via the LXR transcription factors and their regulated genes, the ATP-binding cassette (ABC) cholesterol transporters ABCA1 and ABCG1 ...
Sabrina, Robichaud, Mireille, Ouimet
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Cholesterol efflux capacity: An introduction for clinicians
American Heart Journal, 2016Epidemiologic studies have shown an inverse correlation between high-density lipoprotein (HDL) cholesterol (HDL-C) levels and cardiovascular disease outcomes. However, the hypothesis of a causal relationship between HDL-C and cardiovascular disease has been challenged by genetic and clinical studies.
Malcolm, Anastasius +5 more
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Regulation of cholesterol efflux from macrophages
Current Opinion in Lipidology, 2008The lipid efflux pathway is important for both HDL formation and the reverse cholesterol transport pathway. This review is focused on recent findings on the mechanism of lipid efflux and its regulation, particularly in macrophages.Significant progress has been made on understanding the sequence of events that accompany the interaction of ...
Yves L, Marcel +2 more
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Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis
Journal of Molecular and Cellular Cardiology, 2012Although cholesterol-rich microdomains are highly involved in the functions of cardiomyocytes, the cholesterol homeostasis is largely unknown in these cells. We developed experimental procedures to assess cholesterol synthesis, cholesterol masses and cholesterol efflux from primary cultures of cardiac myocytes obtained from 2 to 4 days old Wistar rats.
Anne, Reboulleau +6 more
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The Effects of Cholesterol Ester Transfer Protein Inhibition on Cholesterol Efflux
The American Journal of Cardiology, 2009Cholesterol ester transfer protein (CETP) deficiency or inhibition results in dramatic elevations of high-density lipoprotein (HDL) levels, but there has been concern that HDL might be dysfunctional in its ability to promote efflux of cholesterol from macrophage foam cells or to mediate reverse cholesterol transport.
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Cholesterol Efflux Capacity and Atherosclerosis
New England Journal of Medicine, 2011de Vries, Rindert +2 more
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Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis
Phytotherapy Research, 2021Saba Soltani +2 more
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