Results 31 to 40 of about 82,690 (331)

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources

Cholesterol efflux from cells enriched with cholesteryl esters by incubation with hypercholesterolemic monkey low density lipoprotein

Journal of Lipid Research, 1983
The mass efflux of free and esterified cholesterol was studied in skin fibroblasts loaded with cholesterol by incubation with low density lipoproteins (LDL) isolated from normal or hypercholesterolemic cynomolgus monkeys.
R W St Clair, M A Leight
doaj   +1 more source

PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection [PDF]

, 2010
Dendritic cells (DCs) contribute to human immunodeficiency virus type 1 (HIV-1) transmission and dissemination by capturing and transporting infectious virus from the mucosa to draining lymph nodes, and transferring these virus particles to CD4+ T cells ...
Blay Puryear, Wendy, Gummuluru, Suryaram, Hanley, Timothy M., Viglianti, Gregory A.   +3 more
core   +5 more sources

Cholesterol Efflux and Atheroprotection [PDF]

Circulation, 2012
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic properties, including the ability to mediate macrophage cholesterol efflux, antioxidant capacity, antiinflammatory properties, nitric oxide–promoting activity, and ability to transport proteins with their own intrinsic biological activities.1 HDL particles are critical
Robert S, Rosenson, H Bryan, Brewer, W Sean, Davidson, Zahi A, Fayad, Valentin, Fuster, James, Goldstein, Marc, Hellerstein, Xian-Cheng, Jiang, Michael C, Phillips, Daniel J, Rader, Alan T, Remaley, George H, Rothblat, Alan R, Tall, Laurent, Yvan-Charvet   +13 more
openaire   +2 more sources

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages

Journal of Lipid Research, 2019
Sphingolipid and cholesterol metabolism are closely associated at the structural, biochemical, and functional levels. Although HDL-associated sphingosine-1-phosphate (S1P) contributes to several HDL functions, and S1P signaling regulates glucose and ...
Mithila Vaidya, Julian A. Jentsch, Susann Peters, Petra Keul, Sarah Weske, Markus H. Gräler, Emil Mladenov, George Iliakis, Gerd Heusch, Bodo Levkau   +9 more
doaj   +1 more source

PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux [PDF]

The Journal of Neuroscience, 2019
The absence of functional peripheral myelin protein 22 (PMP22) is associated with shortened lifespan in rodents and severe peripheral nerve myelin abnormalities in several species including humans. Schwann cells and nerves from PMP22 knock-out (KO) mice show deranged cholesterol distribution and aberrant lipid raft morphology, supporting an ...
Ye Zhou, Joshua R. Miles, Hagai Tavori, Min Lin, Habibeh Khoshbouei, David R. Borchelt, Hannah Bazick, Gary E. Landreth, Sooyeon Lee, Sergio Fazio, Lucia Notterpek   +10 more
openaire   +2 more sources

Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography

Lipids in Health and Disease, 2009
Background Studies in patients with low HDL have suggested that impaired cellular cholesterol efflux is a heritable phenotype increasing atherosclerosis risk.
Kremer Werner, Huber Fritz, Lieb Wolfgang, Mayer Björn, Belz Stefanie, Aherrarhou Zouhair, Jansen Henning, Linsel-Nitschke Patrick, Kalbitzer Hans-Robert, Erdmann Jeanette, Schunkert Heribert   +10 more
doaj   +1 more source

α-Synuclein Regulates Neuronal Cholesterol Efflux [PDF]

Molecules, 2017
α-Synuclein is a neuronal protein that is at the center of focus in understanding the etiology of a group of neurodegenerative diseases called α-synucleinopathies, which includes Parkinson’s disease (PD). Despite much research, the exact physiological function of α-synuclein is still unclear.
Hsiao, JHT, Halliday, GM, Kim, WS, Hsiao, Jen-Hsiang   +3 more
openaire   +4 more sources

Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients [PDF]

, 2016
OBJECTIVE: The functionality of high-density lipoprotein (HDL) is impaired in chronic ischaemic heart failure (HF). However, the relationship between HDL functionality and outcomes in acute HF (AHF) has not been studied.
Berghold, Andrea, Degoricija, Vesna, Dokoza Terešak, Sanda, Frank, Saša, Marsche, Gunther, Potočnjak, Ines, Pregartner, Gudrun, Radulović, Bojana, Tiran, Beate, Trbušić, Matias   +9 more
core   +7 more sources

Importance of macrophage cholesterol content on the flux of cholesterol mass

Journal of Lipid Research, 2010
Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan, Margarita de la Llera-Moya, Denise Drazul-Schrader, Bela F. Asztalos, Ginny L. Weibel, George H. Rothblat   +5 more
doaj   +1 more source