Results 51 to 60 of about 82,690 (331)
Journal of Lipid Research, 1995 We have compared the efflux of cholesterol from different cellular pools of human hepatoma cells HepG2 using intact cells or isolated membrane fractions.
D Sviridov, N Fidge
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Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging
Frontiers in Cell and Developmental Biology, 2022 Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess cholesterol.
Alice Dupont Juhl, Daniel Wüstner
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Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. [PDF]
, 2018 The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear.
Aberg, Judith A +5 more
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Cholesterol efflux in the transplant patient [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2018 Purpose of review Cholesterol metabolism is increasingly recognized in inflammatory diseases including transplantation. This review discusses the mechanistic underpinnings that tie macrophage cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) to chronic rejection in transplanted patients.
Sangita, Sudharshan, Ali, Javaheri
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Journal of Lipid Research, 1997 It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins.
A J Mendez
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]
, 2018 Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John +16 more
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Sesamin Enhances Cholesterol Efflux in RAW264.7 Macrophages [PDF]
Molecules, 2014 Foam cells formation as a result of the uncontrolled cytophagy of modified cholesterol by macrophages plays a key role in the occurrence and development of atherosclerosis. Sesamin is an active constituent of Sesamum indicum which has been shown to possess multiple pharmacological activities. In this work, we investigated the effects of sesamin on foam
Nan Liu +4 more
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Biomedicines, 2021 Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality.
Marina Canyelles +14 more
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Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL [PDF]
Current Opinion in Lipidology, 2015 Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects.We review recent evidence that HDL's cholesterol efflux capacity is a strong ...
Patrick M, Hutchins, Jay W, Heinecke
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The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia
Journal of Lipid Research, 2003 Defects in the gene encoding for the ATP binding cassette (ABC) transporter A1 (ABCA1) were shown to be one of the genetic causes for familial hypoalphalipoproteinemia (FHA). We investigated the role of ABCA1-mediated cholesterol efflux in Dutch subjects
G. Kees Hovingh +6 more
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