Results 41 to 50 of about 53,815 (207)

Polymorphisms at the apoB, apoA-I, and cholesteryl ester transfer protein gene loci in patients with gallbladder disease.

Journal of Lipid Research, 1995
Alterations in lipoprotein levels are reported to be related to an increased risk of gallstones. Plasma lipid metabolism is regulated by a number of proteins that are polymorphic in the population.
T Juvonen, M J Savolainen, M I Kairaluoma, L H Lajunen, S E Humphries, Y A Kesäniemi   +5 more
doaj   +1 more source

Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence. [PDF]

, 2016
Helicobacter pylori infects approximately half of the human population and is the main cause of various gastric diseases. This pathogen is auxotrophic for cholesterol, which it converts upon uptake to various cholesteryl α-glucoside derivatives ...
Chen, Yet-Ran, Chen, Yi-Chi, Gervay-Hague, Jacquelyn, Huang, Yu-Chen, Ingle, Arun B, Jan, Hau-Ming, Lin, Chun-Hung, Liu, Sheng-Wen, Mong, Kwok-Kong Tony, Shih, Yu-Yin, Tu, Zhijay, Wu, Ming-Shiang   +11 more
core   +1 more source

The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis

Journal of Lipid Research, 2009
The plasma lipid transfer proteins promote the exchange of neutral lipids and phospholipids between the plasma lipoproteins. Cholesteryl ester transfer protein (CETP) facilitates the removal of cholesteryl esters from HDL and thus reduces HDL levels ...
David Masson, Xian-Cheng Jiang, Laurent Lagrost, Alan R. Tall   +3 more
doaj   +1 more source

Periodontitis decreases the antiatherogenic potency of high density lipoprotein

Journal of Lipid Research, 2004
Periodontitis, a consequence of persistent bacterial infection and chronic inflammation, has been suggested to predict coronary heart disease (CHD). The aim of this study was to investigate the impact of periodontitis on HDL structure and antiatherogenic
Pirkko J. Pussinen, Matti Jauhiainen, Tiina Vilkuna-Rautiainen, Jouko Sundvall, Marja Vesanen, Kimmo Mattila, Timo Palosuo, Georg Alfthan, Sirkka Asikainen   +8 more
doaj   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Colquhoun, David, Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Olsson, Anders G., Schwartz, Gregory G., Shah, Prediman K., Tardif, Jean-Claude, The dal-OUTCOMES Investigators, Wright, R. Scott   +18 more
core   +2 more sources

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor [PDF]

ACS Medicinal Chemistry Letters, 2019
Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmaceutical properties concomitant with retaining the safety, efficacy, and ...
Heather J. Finlay, Ji Jiang, Richard Rampulla, Mark E. Salvati, Jennifer X. Qiao, Tammy C. Wang, R. Michael Lawrence, Lalgudi S. Harikrishnan, Muthoni G. Kamau, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Christine S. Huang, Ming Chang, Xue-Qing Chen, Paul G. Sleph, Carrie Xu, Julia Li, Paul Levesque, Leonard P. Adam, Ruth R. Wexler   +20 more
openaire   +2 more sources

Preparation and incorporation of probe-labeled apoA-I for fluorescence resonance energy transfer studies of rHDL

Journal of Lipid Research, 2001
Apolipoprotein A-I (apoA-I), the major constituent of HDL, plays an essential role in regulating cholesterol metabolism, acting as the physiological activator of lecithin: cholesterol acyltransferase, which converts cholesterol to cholesterol ester ...
Hui-hua Li, Michael J. Thomas, Wei Pan, Eric Alexander, Michael Samuel, Mary G. Sorci-Thomas   +5 more
doaj   +1 more source

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype [PDF]

, 2014
The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors.
Anne-Marie Allen, Annette Graham, Batarseh, Bird, Borthwick, Borthwick, Brown, Dmitrova-Shumkovska, Engel, Falchi, Farke, Feramisco, Fernandez-Hernando, Gallus, Gerrity, Gut, Hebbachi, Janice M. W. Taylor, Kannel, Khan, Lecanu, Madamanchi, Mercer, Ning, Ning, Ogata, Oram, Pandak, Puddu, Pyper, Rae, Ren, Rigamonti, Rone, Rosenson-Schloss, Rupprecht, Schnoor, Schultz, Taylor, Vanhee, Venkateswaran, Wang, Xu, Yelieev, Zeng, Zeng, Zoltan   +46 more
core   +1 more source

Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences

Journal of Lipid Research, 2008
The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity. Alterations of CETP activity levels
Maruja E. Lira, A. Katrina Loomis, Sara A. Paciga, David B. Lloyd, John F. Thompson   +4 more
doaj   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source