Results 21 to 30 of about 1,765,782 (294)

Cholesteryl ester transfer protein and its inhibitors

Journal of Lipid Research, 2018
Most of the cholesterol in plasma is in an esterified form that is generated in potentially cardioprotective HDLs. Cholesteryl ester transfer protein (CETP) mediates bidirectional transfers of cholesteryl esters (CEs) and triglycerides (TGs) between ...
Sudichhya Shrestha, Ben J. Wu, L. Guiney, P. Barter, K. Rye   +4 more
semanticscholar   +1 more source

Diet modification alters plasma HDL cholesterol concentrations but not the transport of HDL cholesteryl esters to the liver in the hamster

Journal of Lipid Research, 1997
These studies were undertaken to investigate the mechanism whereby diet modification alters the plasma concentration of high density lipoprotein (HDL) cholesteryl ester and apoA-I and to determine whether diet-induced alterations in circulating HDL ...
L A Woollett, D M Kearney, D K Spady
doaj   +1 more source

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans [PDF]

, 1997
Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown.
de Roos, B, Tol, Aad, de Roos, B., de Jong-Caesar, R., Scheek, L.M., Urgert, R., Scheek, L. M., Gent, T, Caesar, R (Ruth), Gent, T. van, Katan, MB, Roos, B. de, van Tol, A., Jong-Caesar, R. de, van Gent, T., Tol, A. van, Scheek, LM (Leo), Urgert, R, Katan, M.B.; id_orcid, Katan, M.B.   +19 more
core   +1 more source

Accumulation and mobilization of triglycerides and cholesteryl esters in Leydig tumor cells.

Journal of Lipid Research, 1992
Incubating MA-10 Leydig tumor cells with sodium oleate led to the accumulation of triglyceride within the cells. Triglycerides were deposited in a time- and dose-dependent fashion. Cellular triglyceride promoted storage of cholesteryl ester.
DA Freeman, JA Ontko
doaj   +1 more source

Phagocytosis of cholesteryl ester is amplified in diabetic mouse macrophages and is largely mediated by CD36 and SR-A. [PDF]

PLoS ONE, 2007
Type 2 diabetes (T2D) is associated with accelerated atherosclerosis, which accounts for approximately 75% of all diabetes-related deaths. Here we investigate the link between diabetes and macrophage cholesteryl ester accumulation.
Christopher B Guest, Matthew E Hartman, Jason C O'Connor, Kenneth S Chakour, Ali A Sovari, Gregory G Freund   +5 more
doaj   +1 more source

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

Cell Metabolism, 2014
Summary Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis at single cell level in human patient cancerous tissues.
Shuhua Yue, Junjie Li, Seung-Young Lee, Hyeon Jeong Lee, Tiansong Shao, B. Song, Liang Cheng, T. Masterson, Xiaoqi Liu, T. Ratliff, Ji‐Xin Cheng   +10 more
semanticscholar   +1 more source

Progesterone blocks intracellular translocation of free cholesterol derived from cholesteryl ester in macrophages.

Journal of Lipid Research, 1995
Macrophage foam cells must accommodate continuing fluxes of free cholesterol in spite of a greatly expanded store of cholesteryl ester. Though endogenous free cholesterol synthesis is suppressed, free cholesterol continues to enter the cell via ...
T Mazzone, M Krishna, Y Lange
doaj   +1 more source

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study

BMC Cancer, 2015
The metabolic effect of intratumor cholesteryl ester (CE) in breast cancer remains poorly understood. The objective was to analyze the relationship between intratumor CE content and clinicopathological variables in human breast carcinomas.
D. de Gonzalo‐Calvo, L. López-Vilaró, L. Nasarre, Maitane Pérez-Olabarría, Tanía Vázquez, D. Escuin, L. Badimón, A. Barnadas, E. Lerma, V. Llorente‐Cortés   +9 more
semanticscholar   +1 more source

Role of the neutral lipid accessible pool in the regulation of secretion of apoB-100 lipoprotein particles by HepG2 cells.

Journal of Lipid Research, 1995
The rate of secretion of apoB-100-containing lipoprotein particles by HepG2 cells is determined to an important extent by post-translational mechanisms, the mass of neutral lipids clearly playing a role in this process.
R.K. Avramoglu, K Cianflone, A.D. Sniderman   +2 more
doaj   +1 more source

Cholesteryl ester-rich microemulsions: stable protein-free analogs of low density lipoproteins.

Journal of Lipid Research, 1982
A method has been devised for the preparation of stable lipid microemulsions containing cholesterol, cholesteryl ester, phosphatidylcholine, and trioleoylglycerol in the relative molar ratios found in low density lipoproteins.
D P Via, I F Craig, G W Jacobs, W B Van Winkle, S C Charlton, A M Gotto, Jr, L C Smith   +6 more
doaj   +1 more source