Results 1 to 10 of about 23,191 (273)

Cholesteryl ester transfer protein and its inhibitors [PDF]

Journal of Lipid Research, 2018
Most of the cholesterol in plasma is in an esterified form that is generated in potentially cardioprotective HDLs. Cholesteryl ester transfer protein (CETP) mediates bidirectional transfers of cholesteryl esters (CEs) and triglycerides (TGs) between ...
Sudichhya Shrestha, Ben J. Wu, Liam Guiney, Philip J. Barter, Kerry-Anne Rye   +4 more
doaj   +6 more sources

Plasma cholesteryl ester transfer protein

Journal of Lipid Research, 1993
AR Tall
doaj   +4 more sources

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia. [PDF]

Mol Neurodegener, 2023
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID).
Poliakova T, Wellington CL.
europepmc   +2 more sources

Cholesteryl Ester Transfer Protein [PDF]

Definitions, 2020
National Cancer Institute
semanticscholar   +3 more sources

Structure-based mechanism and inhibition of cholesteryl ester transfer protein. [PDF]

Curr Atheroscler Rep, 2023
Purpose of Review Cholesteryl ester transfer proteins (CETP) regulate plasma cholesterol levels by transferring cholesteryl esters (CEs) among lipoproteins. Lipoprotein cholesterol levels correlate with the risk factors for atherosclerotic cardiovascular
Xue H, Zhang M, Liu J, Wang J, Ren G.
europepmc   +2 more sources

Cholesteryl Ester Transfer Protein Inhibition Reduces Major Adverse Cardiovascular Events by Lowering Apolipoprotein B Levels. [PDF]

Int J Mol Sci, 2022
Cholesteryl ester transfer protein (CETP) facilitates the exchange of cholesteryl esters and triglycerides (TG) between high-density lipoprotein (HDL) particles and TG-rich, apolipoprotein (apo) B-containing particles.
Nelson AJ, Sniderman AD, Ditmarsch M, Dicklin MR, Nicholls SJ, Davidson MH, Kastelein JJP.   +6 more
europepmc   +2 more sources

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. [PDF]

Nat Commun, 2021
Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from drug target failure, we compared evidence from clinical trials and drug target ...
Schmidt AF, Hunt NB, Gordillo-Marañón M, Charoen P, Drenos F, Kivimaki M, Lawlor DA, Giambartolomei C, Papacosta O, Chaturvedi N, Bis JC, O'Donnell CJ, Wannamethee G, Wong A, Price JF, Hughes AD, Gaunt TR, Franceschini N, Mook-Kanamori DO, Zwierzyna M, Sofat R, Hingorani AD, Finan C.   +22 more
europepmc   +2 more sources

The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction. [PDF]

Biomolecules, 2021
Endothelial dysfunction precedes atherosclerosis and is an independent predictor of cardiovascular events. Cholesterol levels and oxidative stress are key contributors to endothelial damage, whereas high levels of plasma high-density lipoproteins (HDL ...
Wanschel ACBA, Guizoni DM, Lorza-Gil E, Salerno AG, Paiva AA, Dorighello GG, Davel AP, Balkan W, Hare JM, Oliveira HCF.   +9 more
europepmc   +2 more sources

Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population.

JAMA Cardiol, 2022
Importance The balance between the potential long-term clinical benefits and harms associated with genetic cholesteryl ester transfer protein (CETP) deficiency, mimicking pharmacologic CETP inhibition, is unknown.
Nordestgaard LT, Christoffersen M, Lauridsen BK, Afzal S, Nordestgaard BG, Frikke-Schmidt R, Tybjærg-Hansen A.   +6 more
europepmc   +2 more sources

Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events: JACC Review Topic of the Week. [PDF]

J Am Coll Cardiol, 2019
Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl ester between high-density lipoprotein (HDL) and apolipoprotein B100–containing lipoproteins.
Armitage J, Holmes MV, Preiss D.
europepmc   +2 more sources