Results 11 to 20 of about 12,113 (146)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Accelerated cholesteryl ester transfer and altered lipoprotein composition in diabetic cynomolgus monkeys.

Journal of Lipid Research, 1995
To determine whether nonhuman primates demonstrate the same alterations in transport of cholesteryl ester (CE) in plasma observed in diabetic humans, cholesteryl ester transfer (CET) was measured in cynomolgus monkeys with chronic spontaneous diabetes ...
J D Bagdade, J D Wagner, L L Rudel, T B Clarkson   +3 more
doaj   +1 more source

Cholesteryl ester-rich microemulsions: stable protein-free analogs of low density lipoproteins.

Journal of Lipid Research, 1982
A method has been devised for the preparation of stable lipid microemulsions containing cholesterol, cholesteryl ester, phosphatidylcholine, and trioleoylglycerol in the relative molar ratios found in low density lipoproteins.
D P Via, I F Craig, G W Jacobs, W B Van Winkle, S C Charlton, A M Gotto, Jr, L C Smith   +6 more
doaj   +1 more source

Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein.

Journal of Lipid Research, 1993
The direct effect of apolipoprotein (apo) E on cholesteryl ester transfer protein (CETP) activity was studied using lipoproteins from a subject with apoE deficiency (Atherosclerosis. 1991. 88: 15-20) as a model system.
M Kinoshita, H Arai, M Fukasawa, T Watanabe, K Tsukamoto, Y Hashimoto, K Inoue, K Kurokawa, T Teramoto   +8 more
doaj   +1 more source

Cholesteryl ester transfer from phospholipid vesicles to human density lipoproteins.

Journal of Lipid Research, 1981
The exchange of cholesteryl esters between different lipoproteins was reported to bae mediated by a protein present in human plasma. In this study wer have examined the movement of cholesteryl ester from unilamellar phospholipid vesicles to high density ...
P M Young, P Brecher
doaj   +1 more source

Comparative study of phospholipid transfer activities mediated by cholesteryl ester transfer protein and phospholipid transfer protein.

Journal of Lipid Research, 1994
In the present study, a sequential procedure was set up to separate simultaneously cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PTP), and lecithin:cholesterol acyltransferase (LCAT) from human plasma.
L Lagrost, A Athias, P Gambert, C Lallemant   +3 more
doaj   +1 more source

Rat plasma lipoproteins: re-evaluation of a lipoprotein system in an animal devoid of cholesteryl ester transfer activity

Journal of Lipid Research, 1982
Plasma lipoproteins from male rats were isolated by rate zonal centrifugation. Four lipoproteins were identified: VLDL, LDL, HDL1, and HDL2. LDL, HLD1, and some HDL2 distributed within the salt density interval of 1.006-1.085 g/ml, while HDL2 was found ...
Y Oschry, S Eisenberg
doaj   +1 more source

In silico discovery of CETP inhibitors from ZINC15 compounds using docking, ADMET filtering, and molecular dynamics simulations

Research in Pharmaceutical Sciences
Background and purpose: Cholesteryl ester transfer protein is a crucial regulator of lipid metabolism and is considered a promising target for treating atherosclerotic cardiovascular disease. Given the clinical limitations and adverse effects of previous
Kimia Mohammadi, Mojgan Nejabat, Forough Mirabi, Amirhossein Sahebkar, Farzin Hadizadeh   +4 more
doaj   +1 more source

Characterization of cholesteryl ester transfer protein inhibitor from plasma of baboons (Papio sp.)

Journal of Lipid Research, 1993
Selective breeding has produced families of baboons that accumulate large high density lipoproteins (HDL1) when challenged with a high cholesterol and high fat (HCHF) diet.
RS Kushwaha, SQ Hasan, HC McGill, Jr, GS Getz, RG Dunham, P Kanda   +5 more
doaj   +1 more source

Inhibition of lipid transfer by a unique high density lipoprotein subclass containing an inhibitor protein.

Journal of Lipid Research, 1989
We have isolated from human plasma a unique subclass of the high density lipoproteins (HDL) which contains a potent lipid transfer inhibitor protein (LTIP) that inhibited cholesteryl ester, triglyceride, and phospholipid transfer mediated by the lipid ...
T Nishide, J H Tollefson, J J Albers
doaj   +1 more source