Results 191 to 200 of about 15,976 (233)
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Transformation of cholic acid by Arthrobacter simplex
Steroids, 1993Fermentation of cholic acid with Arthrobacter simplex (IICB 227) under aerobic conditions yielded 3,12-dioxo-23,24-dinorchola-4,6-dienoic acid, 7 alpha-hydroxy-3,12-dioxo-23,24-dinorchol-4-enoic acid, 3 alpha, 7 alpha-dihydroxy-12-oxo-5 beta-cholan-24-oic acid, 3 alpha, 7 alpha-dihydroxy-12-oxo-5 beta-23,24-dinorcholan-22-oic acid, 7 alpha, 12 alpha ...
E, Mukherjee, S, Banerjee, S B, Mahato
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Global optimization of cholic acid aggregates
The Journal of Chemical Physics, 2014In spite of recent investigations into the potential pharmaceutical importance of bile acids as drug carriers, the structure of bile acid aggregates is largely unknown. Here, we used global optimization techniques to find the lowest energy configurations for clusters composed between 2 and 10 cholate molecules, and evaluated the relative stabilities of
Balázs, Jójárt +3 more
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Cholic acid derivatives: novel antimicrobials
Expert Opinion on Investigational Drugs, 2000Mimics of squalamine and polymyxin B (PMB) have been prepared from cholic acid in hope of finding new antimicrobial agents. The squalamine mimics include the polyamine and sulphate functionalities found in the parent antibiotic, however, the positions relative to the steroid nucleus have been exchanged.
P B, Savage, C, Li
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Synthesis of amino analogues of cholic acid
Russian Journal of Bioorganic Chemistry, 2011Amino analogues of cholic acid were synthesized by reduction of oximes with combination of titanium(III) chloride and sodium cyanoborohydride.
M A, Maslov +4 more
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Selective inclusion by cholic acid
Journal of the Chemical Society, Chemical Communications, 1993Crystallographic, thermodynamic and molecular mechanics results show that cholic acid enclathrates nitrobenzene in preference to aniline.
Mino R. Caira +2 more
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Catanionic Gels Based on Cholic Acid Derivatives
Langmuir, 2013In this paper, the preparation and characterization of an anionic and a cationic surfactant obtained by chemical modifications of a natural bile acid (cholic acid) are reported. The bile acid was modified by introducing a diamine or a dicarboxylic aromatic residue on the lateral chain.
DI GREGORIO, MARIA CHIARA +7 more
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Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1
Biological Chemistry, 2018Abstract The human cytochrome P450 enzyme CYP8B1 is a crucial regulator of the balance of cholic acid (CA) and chenodeoxycholic acid (CDCA) in the liver. It was previously shown to catalyze the conversion of 7α-hydroxycholest-4-en-3-one, a CDCA precursor, to 7α,12α-dihydroxycholest-4-en-3-one, which is an intermediate of CA biosynthesis.
Linbing, Fan +4 more
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Enzymatic formation of a cholic acid derivative of isethionic acid
Biochemical Pharmacology, 1976Abstract Evidence is presented that preparations of rat liver microsomes are capable of conjugating isethionic acid with cholic acid. Thin-layer chromatography experiments indicate that this newly described conjugated bile acid migrates with the same R f value as taurocholic acid, a structurally similar analogue.
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