Results 11 to 20 of about 343,812 (340)

A MICROBIOLOGICAL METHOD FOR THE DETERMINATION OF CHOLINE BY USE OF A MUTANT OF NEUROSPORA [PDF]

, 1943
Previous communications from this laboratory have described the production of biochemical mutants in the mold Neurospora by means of ultraviolet and x-rays (1, 2).
N. H. Horowitz, G. W. Beadle
openalex   +3 more sources

Choline supplements: An update

Frontiers in Endocrinology, 2023
In this comprehensive review, we examine the main preclinical and clinical investigations assessing the effects of different forms of choline supplementation currently available, including choline alfoscerate (C8H20NO6P), also known as alpha ...
U. Kansakar, V. Trimarco, P. Mone, Fahimeh Varzideh, A. Lombardi, G. Santulli   +5 more
semanticscholar   +1 more source

The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Aerobic glycolysis and abnormal choline phospholipid metabolism are hallmarks of cancer. The inhibition of glycolysis and choline metabolism is a potential strategy for cancer treatment.
Q. Ma, Hongfei Jiang, Leina Ma, Gaoxiang Zhao, Qianqian Xu, Dong Guo, Ningning He, Hao Liu, Zhaoyuan Meng, Juanjuan Liu, Lei Zhu, Qian Lin, Xiaolin Wu, Min Li, Shudi Luo, Jing Fang, Zhimin Lu   +16 more
semanticscholar   +1 more source

Inflammation and the pathological progression of Alzheimer’s disease are associated with low circulating choline levels

Acta Neuropathologica, 2023
Deficiency of dietary choline, an essential nutrient, is observed worldwide, with ~ 90% of Americans being deficient. Previous work highlights a relationship between decreased choline intake and an increased risk for cognitive decline and Alzheimer’s ...
Jessica M Judd, Paniz Jasbi, W. Winslow, G. Serrano, T. Beach, J. Klein-Seetharaman, R. Velazquez   +6 more
semanticscholar   +1 more source

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

npj Biofilms and Microbiomes, 2021
Trimethylamine- N -oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis.
Xingxing Li, Chunyan Su, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang, Jiandong Jiang, B. Hong   +11 more
semanticscholar   +1 more source

Effect of Choline-Based Deep Eutectic Solvent Pretreatment on the Structure of Cellulose and Lignin in Bagasse

Processes, 2021
Deep eutectic solvents (DESs) is a newly developed green solvent with low cost, easy preparation and regeneration. Because of its excellent solubility and swelling effect in lignocellulose, it has received widespread attention and recognition.
Cuicui Li, Chongxing Huang, Yuan Zhao, Chao Zheng, Hongxia Su, Lanyu Zhang, Wanru Luo, Hui Zhao, Shuangfei Wang, Lijie Huang   +9 more
semanticscholar   +1 more source

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

Nutrients, 2020
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver.
N. Arias, S. Arboleya, Joseph Allison, A. Kaliszewska, Sara G. Higarza, M. Gueimonde, J. Arias   +6 more
semanticscholar   +1 more source

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Nutrients, 2020
The foundations of neurodevelopment across an individual’s lifespan are established in the first 1000 days of life (2 years). During this period an adequate supply of nutrients are essential for proper neurodevelopment and lifelong brain function.
E. Derbyshire, R. Obeid
semanticscholar   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Does litomosoides sigmodontis synthesize dimethylethanolamine from choline? [PDF]

, 2008
Juvenile female Litomosoides sigmodontis secrete a protein (Juv-p120) highly modified with dimethylethanolamine (DMAE). In an attempt to establish the source of this decoration worms were pulsed with [3H]-choline and [3H]-ethanolamine and the radio ...
Allen, J E, Allen, Judith, Babayan, S A, Harnett, W, Houston, K M   +4 more
core   +2 more sources