Results 61 to 70 of about 273,862 (336)

Identification and functional analysis of choline transporter in tongue cancer: A novel molecular target for tongue cancer therapy

Journal of Pharmacological Sciences, 2016
We examined the functional characteristics of choline uptake in human tongue carcinoma using the cell line HSC-3. Furthermore, we explored the possible correlation between the inhibition of choline uptake and apoptotic cell death.
Ryohta Nishiyama, Fumiaki Nagashima, Beniko Iwao, Yuiko Kawai, Kana Inoue, Arisa Midori, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inazu   +8 more
doaj   +1 more source

Stretching‐Orientation Reinforced Double Network Solvent‐Free Eutectic Gels for Ultrarobust, Flexible Human‐Machine Interaction Devices

Advanced Functional Materials, EarlyView.
This work develops an ultrarobust, flexible, and solvent‐free eutectic gel featuring stretch‐induced orientation. Overcoming hydrogel limitations, the gel achieves record toughness (133.86 MJ m−3) while integrating strain/temperature/capacitive sensing.
Tingzhong Li, Tongyuan Liu, Qinglu Yu, Yasen Li, Rui Liang, Guoxing Sun   +5 more
wiley   +1 more source

Betaine and Choline Improve Lipid Homeostasis in Obesity by Participation in Mitochondrial Oxidative Demethylation

Frontiers in Nutrition, 2018
We investigated the metabolic effects of betaine (Bet) supplementation on CTP:phosphoethanolamine cytidylyltransferase/Pcyt2 heterozygous mice (HET). HET received either no treatment or were allowed access to 1% Bet supplemented water for 8 weeks.
Sugashan Sivanesan, Adrian Taylor, Junzeng Zhang, Marica Bakovic   +3 more
doaj   +1 more source

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V, Sharpton, Suzanne R, Terrault, Norah A, Yong, Germaine JM   +3 more
core   +1 more source

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis

Advanced Healthcare Materials, EarlyView.
In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo, Bo Li, Hongyi Li, Yi Chen, Qin Yuan, Mingju Shui, Hefeng Zhou, Wei Hao, Shengpeng Wang   +8 more
wiley   +1 more source

Lower Choline Rate in the Left Prefrontal Cortex Is Associated With Higher Amount of Alcohol Use in Alcohol Use Disorder

Frontiers in Psychiatry, 2018
Excessive and long-term alcohol consumption produce metabolic changes, such as of choline, in many brain regions in alcohol use disorder (AUD) and in non-AUD subjects as well.
Rodrigo Stênio Moll de Souza, Rodrigo Stênio Moll de Souza, Rodrigo Stênio Moll de Souza, Rodrigo Stênio Moll de Souza, Marcos Rosa, Thaísa Malbar Rodrigues, Thayssa Dalla Costa Escobar, Thayssa Dalla Costa Escobar, Emerson Leandro Gasparetto, Ester Miyuki Nakamura-Palacios, Ester Miyuki Nakamura-Palacios   +10 more
doaj   +1 more source

Assessing Urinary Metabolomics in Giant Pandas Using Chromatography/Mass Spectrometry: Pregnancy-Related Changes in the Metabolome

Frontiers in Endocrinology, 2020
Giant pandas represent one of the most endangered species worldwide, and their reproductive capacity is extremely low. They have a relatively long gestational period, mainly because embryo implantation is delayed.
Maosheng Cao, Chunjin Li, Yuliang Liu, Kailai Cai, Lu Chen, Chenfeng Yuan, Zijiao Zhao, Boqi Zhang, Rong Hou, Xu Zhou   +9 more
doaj   +1 more source

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

Biosynthesis of phosphatidyl choline during prenatal development of the rat lung

Journal of Lipid Research, 1968
The biosynthesis of phosphatidyl choline in rat lung during prenatal development is of interest in connection with the mechanisms of functional development of the lung, particularly in relation to the production of lung surfactant and the control of ...
Paul A. Weinhold
doaj