Results 71 to 80 of about 343,812 (340)

Betaine and Choline Improve Lipid Homeostasis in Obesity by Participation in Mitochondrial Oxidative Demethylation

Frontiers in Nutrition, 2018
We investigated the metabolic effects of betaine (Bet) supplementation on CTP:phosphoethanolamine cytidylyltransferase/Pcyt2 heterozygous mice (HET). HET received either no treatment or were allowed access to 1% Bet supplemented water for 8 weeks.
Sugashan Sivanesan, Adrian Taylor, Junzeng Zhang, Marica Bakovic   +3 more
doaj   +1 more source

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

Scientific Reports, 2016
Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk of cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD).
Yu-ming Chen, Yan Liu, Rui-fen Zhou, Xiao-ling Chen, Cheng Wang, Xu-ying Tan, Li-jun Wang, Rui-dan Zheng, Hong-wei Zhang, W. Ling, Hui-lian Zhu   +10 more
semanticscholar   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Impact of dietary changes on hepatic homocysteine metabolism in young broilers [PDF]

, 2004
Information regarding the impact of sulfur amino acids (SAA) on hepatic homocysteine (Hcy) flux through the various metabolic pathways competing for Hcy in young broilers is lacking. An experiment was conducted to evaluate the impact of varying levels of
Emmert, Jason L., Ganson, Fauna M., Pillai, Padmakumar   +2 more
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Effects of supplementary choline on quail meat and fatty liver

Revista Brasileira de Zootecnia
The objective of this study was to investigate the effects of supplementary choline on amount of choline passing to quail meat and reduction of fat deposition in liver.
Süleyman Ercüment Önel, Şana Sungur, Mikail Baylan   +2 more
doaj   +1 more source

Dietary choline supplementation attenuated high-fat diet-induced inflammation through regulation of lipid metabolism and suppression of NFκB activation in juvenile black seabream (Acanthopagrus schlegelii)

Journal of Nutritional Science, 2019
The present study aimed to investigate whether dietary choline can regulate lipid metabolism and suppress NFκB activation and, consequently, attenuate inflammation induced by a high-fat diet in black sea bream (Acanthopagrus schlegelii).
Min Jin, Tingting Pan, D. Tocher, M. Betancor, Ó. Monroig, Yuedong Shen, Tingting Zhu, P. Sun, Lefei Jiao, Qi-cun Zhou   +9 more
semanticscholar   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Baker, D, Giovannoni, G, Jackson, SJ
core   +3 more sources

Effects of Rumen-Protected Methionine, Choline, and Betaine Supplementation on Ewes’ Pregnancy and Reproductive Outcomes

Veterinary Sciences
This study evaluated the effects of maternal supplementation with rumen-protected methionine (RPM), alone or combined with rumen-protected choline (RPC) and betaine (RPB), during the periconceptional and prepartum periods on reproductive outcomes and ...
Basiliki Kotsampasi, Eleni Tsiplakou, Maria-Anastasia Karatzia, Stavroula Oikonomou, Christina Mitsiopoulou, Dimitris Kalogiannis, Eleni Dovolou, Aristotelis Lymperopoulos, Kyriaki Sotirakoglou, Maria Anastasiadou, George Zervas, Stella Chadio   +11 more
doaj   +1 more source